Gist cytology pathology outlines

  • What are the histological findings of GIST?

    Histologically, these tumors have a wide variation ranging from hypocellular to highly cellular with higher mitotic rates in the latter group.
    The majority of gastric GISTs are spindle cell tumors, but approximately 20–25% have epithelioid morphology..

  • What are the markers for GIST pathology?

    The two most important immunohistochemical markers for the histopathological identification of GIST are KIT and anoctamin 1.
    KIT is a type III receptor tyrosine kinase transmembrane protein, a growth factor receptor for stem cell factor..

  • What is a GIST in pathology?

    A gastrointestinal stromal tumor (GIST) is a type of cancer that begins in the digestive system.
    GIST s happen most often in the stomach and small intestine.
    A GIST is a growth of cells that's thought to form from a special type of nerve cells..

  • What is the morphology of GIST?

    Morphologically, GISTs show a wide spectrum of morphologies, from bland spindle cell proliferations to highly cellular epithelioid tumors with significant nuclear pleomorphism (Figure 1).
    For these reasons, the morphologic differential diagnosis is necessarily broad (Table 1)..

  • Tests for GIST

    1. Ultrasound scan.
      2. An ultrasound scan uses soundwaves to form a picture of the inside of the body.
    2. Endoscopy.
      3. This test uses a thin tube called an endoscope which has a light and camera on the end.
    3. Endoscopic ultrasound (EUS)
    4. Colonoscopy
    5. Biopsy
    6. CT scan
    7. MRI scan
    8. PET scan
  • A GIST is considered high risk if the tumor is \x26gt;10 cm with any mitotic index, the tumor is \x26gt;5 cm with a mitotic count \x26gt;5/50 HPF, or if the tumor has ruptured (Table 4) (30).
  • The stages for gastrointestinal stromal tumors (GIST) range from I (1) through IV (4).
    As a rule, the lower the number, the less the cancer has spread.
    A higher number, such as stage IV, means cancer has spread more.
    And within a stage, an earlier letter means a lower stage.
Cytology description | Cytology images | Positive stains | Negative stains Extragastrointestinal GIST: GIST arising outside of the gastrointestinal tract 
GISTSDH is an enzyme complex in the electron transport chain and Krebs (citric acid) cycle, composed of four subunits (SDHA, SDHB, SDHC, SDHD)In the Krebs 

What is the cytomorphology of gastrointestinal stromal tumor (GIST)?

Cytomorphology of the tumor cells can change, usually adopting a more epithelioid and even anaplastic or sarcomatoid appearance Gastrointestinal stromal tumor (GIST), spindle cell type, 3

0 cm, grade 1 (see synoptic report for risk stratification as well as biomarker report) Positive for pancytokeratin and negative for CD117 and DOG1

What is the differential diagnosis of GIST?

Furthermore, GIST can manifest as bone or soft tissue metastasis, so that tumors histologically potentially compatible with GIST and not otherwise recognized should also be tested for GIST markers

The differential diagnosis of GIST is rather broad and includes a number of entities, most of which are much less common than GIST

What should a pathologist know about Gist?

Although GIST is now a well-recognized entity, the pathologist must be aware of the wide morphologic spectrum of GISTs, including the common morphologic subgroups, the unusual morphologic variants, and the morphologic changes that may be encountered after treatment


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