Can cytology be wrong?
Fine-needle aspiration cytology (FNAC) is an efficient and reliable means for the evaluation of thyroid nodules and is considered the gold standard for preoperative diagnoses [2,3,4].
At the same time, FNA of thyroid nodules has limitations in that both false-negative and false-positive results can occur [5, 6]..
What are the limitations of cytopathology?
The main limitations of cytological samples are related to (1) the multitude of cytologic substrates and fixatives that require additional test validation as the majority of molecular assays are developed on FFPE tissue blocks, (2) the limited cellularity and the nucleic acid yield especially when the neoplastic cells .
What are the pitfalls in cytology?
Well-known pitfalls are severe nuclear atypia in fibroadenoma of the breast, cytological atypia in reactive fibrohistiocytic lesions, low-grade nodular lymphoma versus reactive lymphadenopathy, and branchial cyst versus cystically degenerate squamous cell carcinoma.
Other pitfalls are encountered only rarely..
What are the pitfalls in cytology?
Well-known pitfalls are severe nuclear atypia in fibroadenoma of the breast, cytological atypia in reactive fibrohistiocytic lesions, low-grade nodular lymphoma versus reactive lymphadenopathy, and branchial cyst versus cystically degenerate squamous cell carcinoma.
Other pitfalls are encountered only rarely.Jul 22, 2003.
What are the pitfalls of fluid cytology?
surface tension-related alterations in cytomorphology.improper specimen processing.Many faces of reactive mesothelial cells, overlapping with those of cancer cells.proliferation-related features.degenerative changes, such as nuclear hyperchromasia and cytoplasmic vacuolation.unexpected patterns and unusual entities..
What are the pitfalls of FNAC?
Understanding the pitfalls in FNAC of thyroid like inadequate specimen, inaccurate selection of specimen site, inaccuracy in interpretation, interpretation errors, cysts, follicular lesions, Hurthle cell lesions and lymphocytic lesions and correcting them by getting aspirate from different portions of the nodule, Ultra .
- Fine-needle aspiration cytology (FNAC) is an efficient and reliable means for the evaluation of thyroid nodules and is considered the gold standard for preoperative diagnoses [2,3,4].
At the same time, FNA of thyroid nodules has limitations in that both false-negative and false-positive results can occur [5, 6]. - Understanding the pitfalls in FNAC of thyroid like inadequate specimen, inaccurate selection of specimen site, inaccuracy in interpretation, interpretation errors, cysts, follicular lesions, Hurthle cell lesions and lymphocytic lesions and correcting them by getting aspirate from different portions of the nodule, Ultra
