Cytology vs histology breast cancer

  • Can cytology detect breast cancer?

    Pooled results yielded a sensitivity of cytology of nipple discharge for the diagnosis of breast cancer of 63% (95% CI: 53%–72%) and a specificity of 95% (95% CI: 87%–98%) [Figures ​3 and ​ 4]..

  • How is breast cancer cytology classified?

    The International Academy of Cytology Yokohama System has developed a standardized system of reporting breast cytology by classifying them into five categories – insufficient, benign, atypical, suspicious, and malignant..

  • What is the histology of breast cancer?

    Histology and Grading of HR-Positive (Luminal-Like) Breast Cancer.
    A variety of histomorphological subtypes and grades can be seen in luminal(-like) breast cancer.
    Some display tubular structures with low nuclear pleomorphism, some grow in a solid pattern, and some exhibit high-grade nuclei..

  • What is the role of histopathology in breast cancer?

    Breast cancer diagnosis consists of a screening test such as mammography or ultrasound whenever a lump is detected, followed by a biopsy and histopathological examination to make a definite diagnosis of any malignant growth in the breast tissue..

  • Invasive breast cancer (ILC or IDC)
    The most common types are invasive ductal carcinoma and invasive lobular carcinoma.
    Invasive ductal carcinoma makes up about 70-80% of all breast cancers.
  • Most patients present with a bulky palpable mass with axillary lymphadenopathy.
    Histologically, medullary carcinomas have cells that are poorly differentiated (high grade), grow in a syncytial pattern, and have an intense associated lymphoplasmacytic infiltrate.
  • The most common special histological types of breast cancer include: medullary carcinoma, metaplastic carcinoma, apocrine carcinoma, mucinous carcinoma, cribriform carcinoma, tubular carcinoma, neuroendocrine carcinoma, classic lobular carcinoma, and pleomorphic lobular carcinoma, in addition to the non-specific type
The concordance rate between grade I tumors on cytology and histology was 78.57%, while for grade II tumors it was 79.31% and for grade III tumors it was 71.42%  AbstractMaterials and MethodsResultsDiscussion

Are cytological and histological grading of breast cancer related?

It is a prospective study done on fifty cases of breast cancer reported on cytology

Fifty patients who underwent FNAC and mastectomy for breast carcinoma were cytologically and histologically graded

Correlation between cytological and histological grading system was determined

What is the concordance rate between cytology and histology?

The concordance rate between grade I tumors on cytology and histology was 78

57%, while for grade II tumors it was 79

31% and for grade III tumors it was 71 42%

Thirty-nine cases out of 50 cases showed an agreement between the respective cytological and histological grades

The absolute concordance rate was 78%

What is the heterogeneity of breast cancer cells?

Carcinoma of the breast is a truly complex disease with a large intertumoral and intratumoral heterogeneity, leading to markedly variable clinical course and response to treatment modalities

There are only a few data that have explained the heterogeneity of cells within a tumor; in general, this feature is not fully understood

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Histology is the study of the structure and function of cells. Cytology is the study of the structure and function of cells and tissues under a microscope. Histology provides a more complete view of how cancer cells behave, while cytology provides a more detailed view of specific cell types in cancer.The main difference between the two is that histology studies the macrocellular array of cells that makes up plant and animal tissues, whereas cytology examines individual cells or cluster of cells to see how cells work in different areas of the body in order to make diagnosis of certain diseases, including some forms of cancer.While cytopathology relates to abnormalities found within—or expressed by—individual cells, histopathology extends the analysis so that pathologists can see abnormalities related to attachments between cells, and explore whether the cell appears normal given its location within the tissue.

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