Antimetabolites biochemistry

  • How are antimetabolites and an inhibitor of nucleic acid synthesis?

    Antimetabolites disrupt nucleic acid synthesis by interfering with production of a major nucleotide metabolite or by substituting for the natural metabolite.
    Like most cytotoxic anticancer agents, antimetabolites are toxic to normal cells, especially those in the bone marrow and gastrointestinal tract..

  • What are antimetabolites in biochemistry?

    antimetabolite, a substance that competes with, replaces, or inhibits a specific metabolite of a cell and thereby interferes with the cell's normal metabolic functioning.Sep 22, 2023.

  • What are microbial antimetabolites?

    An antimetabolite is a structural analog of an essential metabolite, vitamin, hormone, or amino acid, which is able to cause signs of deficiency of the essential metabolite in some living thing or in some biological reaction..

  • What is an antimetabolites?

    Antimetabolites are defined as interfering with the synthesis of the DNA constituents; they are structural analogues, either of purine and pyrimidine bases (or the corresponding nucleosides), or of folate cofactors, which are involved at several steps of purine and pyrimidine biosynthesis..

  • What is the difference between metabolites and antimetabolites?

    An antimetabolite is a substance that prevents the usage of a metabolite, which is a molecule that occurs naturally in the body's metabolism.
    Antimetabolites are often structurally identical to the metabolite they interfere with, such as antifolates, which interfere with the usage of folic acid..

  • What is the mechanism of antimetabolites in medicinal chemistry?

    Their first mechanism of action is, therefore, to induce depletion in nucleotides inducing in turn an inhibition of DNA replication.
    However, some of them are able to get inserted fraudulently into nucleic acids, inducing structural abnormalities leading to cell death by other mechanisms, including DNA breaks..

  • What is the mechanism of antimetabolites?

    Antimetabolites interfere with DNA and RNA synthesis by acting as false metabolites, which are incorporated into the DNA strand or block essential enzymes, so that DNA synthesis is prevented.
    Most agents are cell cycle phase specific for S phase..

  • What is the pharmacokinetics of antimetabolites?

    Pharmacodynamics and pharmacokinetics of antimetabolites.
    Antimetabolites are administered in the form of a base or its riboside, which is incorporated into the cell and converted to an active or inactive metabolite..

  • What is the principle of antimetabolites?

    Antimetabolites interfere with DNA and RNA synthesis by acting as false metabolites, which are incorporated into the DNA strand or block essential enzymes, so that DNA synthesis is prevented.
    Most agents are cell cycle phase specific for S phase..

  • What is the purpose of antimetabolites?

    Antimetabole, when used in spoken or written language, involves inverting the words used in the first half of a sentence in the second half of a sentence to create emphasis through repetition..

  • An antimetabolite is a substance that prevents the usage of a metabolite, which is a molecule that occurs naturally in the body's metabolism.
    Antimetabolites are often structurally identical to the metabolite they interfere with, such as antifolates, which interfere with the usage of folic acid.
  • Antimetabolites as antibiotics that inhibit synthesis of nucleotides needed for nucleic acid synthesis and their mechanisms of action are discussed.
    Background biochemistry on folic acid metabolism is included.
    Antibiotics presented are sulfa drugs, p-aminosalicylic acid, dapsone, trimethoprim, and fluorouracil.
  • Antimetabolites disrupt nucleic acid synthesis by interfering with production of a major nucleotide metabolite or by substituting for the natural metabolite.
    Like most cytotoxic anticancer agents, antimetabolites are toxic to normal cells, especially those in the bone marrow and gastrointestinal tract.
  • The basic mechanism of action of purine and pyrimidine antimetabolites is similar.
    These compounds diffuse into cells (usually with the aid of a membrane transporter1) and are converted to analogues of cellular nucleotides by enzymes of the purine or pyrimidine metabolic pathway.
Anti-metabolites masquerade as a purine (azathioprine, mercaptopurine) or a pyrimidine, chemicals that become the building-blocks of DNA. They prevent these substances from becoming incorporated into DNA during the S phase (of the cell cycle), stopping normal development and cell division.
Sep 22, 2023An antimetabolite is similar in structure to a metabolite, or enzymatic substrate, which is normally recognized and acted upon by an enzyme to 
Antimetabolites act by mimicking purines and pyrimidines that are required for DNA synthesis or by interfering with native synthesis. They most commonly affect cells in the S phase of the cell cycle (cell-cycle specific) when DNA replication is occurring (Table 2.6).
Antimetabolites can cause either DNA damage indirectly through misincorporation into DNA followed by abnormal timing or progression through DNA synthesis, or altered function of enzymes involved in pyrimidine and purine synthesis.
Antimetabolites generally impair DNA replication machinery, either by incorporation of chemically altered nucleotides or by depleting the supply of deoxynucleotides needed for DNA replication and cell proliferation.

How do anti-metabolites affect RNA synthesis?

Anti-metabolites masquerade as a purine ( azathioprine, mercaptopurine) or a pyrimidine, chemicals that become the building-blocks of DNA.
They prevent these substances from becoming incorporated into DNA during the S phase (of the cell cycle ), stopping normal development and cell division. Anti-metabolites also affect RNA synthesis.

How do antimetabolites affect apoptosis?

Antimetabolites are drugs that hamper the production of DNA or RNA by competition for binding sites of enzymes that participate in essential biosynthetic processes.
The action of these compounds may also result from their incorporation into nucleic acids, which inhibits the normal function of nucleic acids and triggers the apoptosis process.

What are examples of cancer drug antimetabolites?

Examples of cancer drug antimetabolites include, but are not limited to the following:

  • Anti-metabolites masquerade as a purine ( azathioprine
  • mercaptopurine) or a pyrimidine
  • chemicals that become the building-blocks of DNA.

    • What is an antimetabolite in biology?

    Antimetabolite, a substance that competes with, replaces, or inhibits a specific metabolite of a cell and thereby interferes with the cell’s normal metabolic functioning.
    An antimetabolite is similar in structure to a metabolite, or enzymatic substrate, which is normally recognized and acted upon .

    Chemical that inhibits the use of a metabolite

    An antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism.
    Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid; thus, competitive inhibition can occur, and the presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

    Chemical that inhibits the use of a metabolite

    An antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism.
    Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid; thus, competitive inhibition can occur, and the presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

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