A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence
15 juil. 2022 Thus specifically targeting ALDH1A1 could be an effective strategy to inhibit cancer stemness and disease relapse. We describe the discovery of ...
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer
12 mar. 2019 Although. ALDH1A1 is expressed in all cell lines tested ALDH1A3 is the dominant isoform in OVCAR8
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A Novel ALDH1A1 Inhibitor Targets Cells with Stem Cell
8 avr. 2019 Keywords: ovarian cancer; ALDH1A1; CM37; cancer stem cells ... inhibitor for ALDH1A1 discovered from a high-throughput screen of a diverse ...
A novel ALDH1A1 inhibitor blocks platinum-induced senescence
10 mai 2022 We identified a first in class ALDH1A1 inhibitor compound 974
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A novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senes- cence
2 mai 2022 We describe the discovery of a novel ALDH1A1 inhibitor called 974 and ... thermore inhibiting ALDH1A1 suppresses chemotherapy induced ...
Discovery of Orally Bioavailable Quinoline-Based Aldehyde
16 mai 2018 Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular. Activity ... potent and selective ALDH1A1 inhibitor NCT-501 (4) derived.
ALDH1A1 Contributes to PARP Inhibitor Resistance via Enhancing
ovarian cancer cells. Our findings provide a novel mechanism underlying PARPi resistance in BRCA2-mutated EOC cells and suggest that inhibition of ALDH1A1 could
Investigation of an ALDH1A1-specific inhibitor for suppression of
1 mai 2021 Based on these reports we hypothesized that a specific inhibitor of ALDH1A1 would suppress weight gain without causing hepatic lipidosis or ...
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Figure S1. X-Ray Crystallography of CM38 with ALDH1A1 and
X-Ray Crystallography of CM38 with ALDH1A1 and characterization of inhibitor activ- ity (A). Structure of Human ALDH1A1 with bound compound CM38.
The role of aldehyde dehydrogenase 1A1 in B-cell non-Hodgkin's
11 jan. 2018 We demonstrated that inhibition of ALDH1A1 increased the sensitivity of Raji cells to CHOP as indicated by increased cytotoxicity