ALDH1L2 Knockout in U251 Glioblastoma Cells Reduces Tumor
30 avr. 2022 cancer stem cells of U251 methionine independent. ... Keywords: tumor sphere; glioblastoma; methionine; ROS; ALDH1L2. 1. Background.
ALDH1L2 Knockout in U251 Glioblastoma Cells Reduces Tumor
30 avr. 2022 of the cancer stem cells of U251 methionine independent. ... Keywords: tumor sphere; glioblastoma; methionine; ROS; ALDH1L2. 1. Background.
Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the
30 oct. 2015 Cytosolic folate metabolism is sufficient to support tumor growth. Authors ... duce mitochondrial NADPH via the enzyme ALDH1L2 and.
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Deleterious mutations in ALDH1L2 suggest a novel cause for neuro
18 sept. 2019 with deleterious mutations in the ALDH1L2 (aldehyde dehydrogenase 1 family member ... Cancer Center Core Support Grant to the UNC Lineberger ...
The importance of mitochondrial folate enzymes in human colorectal
dehydrogenase 1 family member L2 (ALDH1L2) were upreg- ulated in human colorectal tumor tissues compared to normal tissues. Colorectal cancer tissue
The one-carbon metabolism pathway highlights therapeutic targets
MTHFD2 and ALDH1L2 which play critical roles in the cancer survival and proliferation presumably through purine production. In the methionine cycle
Aldh1l2 knockout mouse metabolomics links the loss of the
Keywords: ALDH1L2 Folate metabolism
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The mitochondrial one‑carbon metabolic pathway is associated with
17 mars 2017 cancer. Mitochondrial one-carbon metabolism comprises a ... dehydrogenase 1 family member L2 (ALDH1L2) and serine.
Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in
of 1C metabolism in cancer cells including the critical role of the elevated in many tumor types (90) and ALDH1L2 was implicated in.
Mitochondrial One-Carbon Pathway Supports Cytosolic Folate
29 nov. 2018 Cytosolic Folate Integrity in Cancer Cells. Graphical Abstract. Highlights ... The mitochondrial isoform ALDH1L2 is expected to facilitate.
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