[PDF] CHEM-UA 890 Advanced Biochemistry - Arts & Science - NYU

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30006_7AdvancedBiochem2020_syllabus_initial1.pdf

CHEM-UA 890 Advanced Biochemistry (Spring 2020) Lectures: Monday, Wednesday 12:30-1:45. 7 E. 12th Street, Room LL23 Recitations: On Tuesdays, as announced. Office hours: Fridays 2-3:30 pm, Silver room 821, or by arrangement. Suggested textbook: Wilson & Walkers' Principles and Techniques of Biochemistry and Molecular Biology, Cambridge. Optional additional textbook: Miesfeld & McEvoy, Biochemistry, Norton. Journal articles will be posted on NYU Classes to supplement the textbook. General information. This is an advanced undergraduate-level biochemistry course that develops themes introduced in BIochemistry. Over the course of one semester, we will cover topics that include techniques in regulation of gene expression; cellular protein synthesis, foldin g and degradati on; biosynthesis of natural products; modern techniques in chemical genetics and proteomics; carbohydra te, lipid, amino acid, nucleotide, and amino acid metabolism; and p rotein channel s and pumps that mediate metal transport. At the end of the semester, students will present a literature topic as part of a team in order to encourage reading of primary scientific literature and to improve communication skills. Instructors: Prof. Kent Kirshenbaum, Room: Silver 821 Email: kent@nyu.edu Prof. Somdeb Mitra, Room: Silver 1001S Email: sm7274@nyu.edu Recitation Sections Section Instructor Schedule Location 102 Somdeb Mitra Tuesday 9:30 AM to 10:45 AM 60 5th Ave., Room 165 103 Somdeb Mitra Tuesday 12:30 PM to 1:45 PM 25 W4, C-13

SCHEDULE OF LECTURES Lecture, Date Topic Reading* Recitation 1. Jan. 27 M Overview of course, Review of Fundamentals 2, Jan. 29 W Protein Purification & Centrifugation M&M 5.1; W&W 5, 12 3, Feb. 3 M Spectroscopy I W&W 13 Rec. 1 4, Feb. 5 W Spectroscopy II W&W 13 5, Feb. 10 M Structure Determination I M&M 5.3 Rec. 2 6, Feb. 12 W Structure Determination II, (Traaseth) M&M 5.3 Feb. 17 M President's Day - No Class Rec. 3 7, Feb. 19 W Motor Proteins M&M 6.4 8, Feb. 24 M Cell Signaling I M&M 8 Rec. 4 9, Feb. 26 W Cell Signaling II M&M 8 Mar. 2 M Midterm 1, Lectures 1-9 10, Mar. 4 W Bioconjugate Chemistry additional 11, Mar. 9 M Immunochemistry I M&M 5.4; W&W 7 Rec. 5 12, Mar. 11 W Immunochemistry II M&M 5.4; W&W 7 Mar 16-22 Spring Break 13, Mar. 23 M Mass Spectrometry & Proteomics I W&W 13, 21 Rec. 6 14, Mar. 25 W Proteomics and other -omics II W&W 22 15, Mar. 30 M Protein Folding I M&M 4.3 Rec. 7 16, Apr. 1 W Protein Folding II & Intrinsically Disordered Proteins journal article Apr. 6 M Midterm 2, Lectures 10-16 17, Apr. 8 W Protein Folding Diseases journal article 18, Apr. 13, M Medicinal Chemistry I M&M 24 Rec. 8 19 Apr. 15 W Medicinal Chemistry II M&M 24 20, Apr. 20, M Protein Therapeutics & Immunotherapies journal article Rec. 9 21, Apr. 22, W Protein Therapeutics II & Therapies for Protein Folding Diseases journal article 22, Apr. 27 M Presentations I Apr. 29 W Final Exam, comprehensive 24, May 4, M Presentations II 25, May 6 W Presentations III 26, May 11 M Presentations IV M = Monday, W = Wednesday Reading: M&M = Miesfeld & McEvoy, W&W = Wilson & Walker

Grades and Exams: Your course gra de will be determined in pa rt by scores on examinations. Two midterm exams will each be worth 100 points. The final exam will be cumulative, and will be worth 200 points. Note that the final exam will be in class, and is currently scheduled for Apri l 29, subject to modificat ion. Please be aware th at an unexcused absence from any exam results in a score of zero for that exam. (Please ensure that absence notifications are from NYU student health) Exam Regrade Policy: • Do not make any marks on the exam. • On a separa te, ha nd-signed cover sheet stap led to the exam, list your emai l address, state the problems that were misgraded, and affirm that no changes to the exam were made after grading. • Submit the regrade request within two days of receiving the graded exam. • Arithmetic errors in adding up points will be corrected immediately. Any other regrade request will cause the entire exam to be regraded; therefore, your overall score may increase or decrease. • Oral or late requests for regrading will not be accepted. Recitation Quizzes. An additional 100 points will be awarded for quizzes conducted in recitation sections. Recitations will review the lectures, discuss journal articles, provide additional problems, and allow overviews prior to exams. Please be sure that you have an assigned recitation section. Missing three or more recitations for any reason at all will result in an incomplete for the class. Team Essay/Presentations. To encourage you to read primary scientific literature, we will award 100 points for a team essay and presentation that evaluates a recent journal article relevan t to the course material. The format of this assignment is (a ) to summarize the objectives, methods, and conclusions of a recent article and (b) to propose the next set of experiments to advance this research effort. Students will work in teams of two. One student will be responsible for the essay and presentation for section (a) and the other student will be responsible for section (b). Each essay should be two pages long. The presentations will take place during the last 3 weeks of the class; more information will be provided in lectures and the recitation sections. Overall Grading: Activity Points Midterm 1 100 Midterm 2 100 Final exam 200 Recitation quizzes 100 Essay/Presentation 100 Total 600

Class website: This course is on NYU Classes. Notes, readings, problem sets, study guides, modules and web links as well as answers to problems will all be posted on the web. Lectures will often be posted prior to each class (except Lecture 1) and should be printed and brought to class. Academic Integrity and Plagiarism: The instructors for this course have no tolerance for plagiarism in any manifestation. The NYU policy on plagiarism will be enforced with great vigil. Students who fail to conform to NYU's standards on academic integrity will be subject to stringent discipli nary action . Inform yourself in advan ce of proper academic conduct. In brief (and quoting from the College of Arts & Science policy), "Academic honesty means that the work you submit - in whatever form - is original." When in doubt, ask. Please consult: http://cas.nyu.edu/page/academicintegrity 1

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