[PDF] Draft Toxicological Profile for 1,3-Butadiene

39364_7tp28.pdf

TOXICOLOGICAL PROFILE FOR

1,3 -

BUTADIENE

DISCLAIMER

UPDATE STATEMENT

Federal Register

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QUICK REFERENCE FOR HEALTH CARE PROVIDERS

Primary Chapters/Sections of Interest

Chapter 1: Public Health Statement

Chapter 2: Relevance to Public Health

Chapter 3: Health Effects

NOTE

Pediatrics

Section 1.6 How Can (Chemical X) Affect Children?

Section 1.7 How Can Families Reduce the Risk of Exposure to (Chemical X)?

Section 3.7 Children's Susceptibility

Section 6.6 Exposures of Children

Other Sections of Interest:

Section 3.8 Biomarkers of Exposure and Effect

Section 3.11 Methods for Reducing Toxic Effects

ATSDR Information Center

Phone: Fax:

E-mail: InternetKWWSZZZDWVGUFGFJRY

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Case Studies in Environmental Medicine: Taking an Exposure History Reproductive and Developmental Hazards; Skin Lesions and Environmental Exposures; Cholinesterase-Inhibiting Pesticide

Toxicity

Managing Hazardous Materials Incidents

Medical Management Guidelines for Acute Chemical Exposure

Fact Sheets (ToxFAQs)

Other Agencies and Organizations

The National Center for Environmental Health

The National Institute for Occupational Safety and Health The National Institute of Environmental Health Sciences

Referrals

The Association of Occupational and Environmental Clinics )$; ‡HPDLO$2(&#$2(&25*‡:HE3DJH KWWSZZZDRHFRUJ The American College of Occupational and Environmental Medicine

CONTRIBUTORS

CHEMICAL MANAGER(S)/AUTHOR(S):

THE PROFILE HAS UNDERGONE THE FOLLOWING ATSDR INTERNAL REVIEWS:   

PEER REVIEW

  

CONTENTS

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1. PUBLIC HEALTH STATEMENT

1.1 WHAT IS 1,3-BUTADIENE?

Description

Uses

1.2 WHAT HAPPENS TO 1,3-BUTADIENE WHEN IT ENTERS THE ENVIRONMENT?

Sources

Break-down

• Air • Water and soil

1.3 HOW MIGHT I BE EXPOSED TO 1,3-BUTADIENE?

Air

Workplace air

Food and drinking water

Gasoline

1.4 HOW CAN 1,3-BUTADIENE ENTER AND LEAVE MY BODY?

Enter your body

Leave your body

1.5 HOW CAN 1,3-BUTADIENE AFFECT MY HEALTH?

Noncancer

Cancer

1.6 HOW CAN 1,3-BUTADIENE AFFECT CHILDREN?

Effects in children

Birth defects

1.7 HOW CAN FAMILIES REDUCE THE RISK OF EXPOSURE TO 1,3-BUTADIENE?

Wood burning

Vehicle engines

Vehicle traffic

Tobacco smoke

1.8 IS THERE A MEDICAL TEST TO DETERMINE WHETHER I HAVE BEEN EXPOSED TO 1,3 -BUTADIENE?

Development of blood

tests 1.9 WHAT RECOMMENDATIONS HAS THE FEDERAL GOVERNMENT MADE TO

PROTECT HUMAN HEALTH?

Levels in breathing air

set by EPA

Levels in drinking water

set by EPA

Levels in workplace air

set by OSHA

1.10 WHERE CAN I GET MORE INFORMATION?

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2. RELEVANCE TO PUBLIC HEALTH

2.1 BACKGROUND AND ENVIRONMENTAL EXPOSURES TO 1,3-BUTADIENE IN THE

UNITED STATES

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3. HEALTH EFFECTS

3.1 INTRODUCTION

3.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE



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Table 3-1 Levels of Significant Exposure to 1,3-butadiene - Inhalation a

Key to

Figure Species

(Strain) Exposure/

Duration/

Frequency

(Route)

ACUTE EXPOSURE Death

1

System

NOAEL

(ppm) Less Serious (ppm) LOAEL

Serious

(ppm) Reference

Chemical Form

Comments

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Systemic

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Table 3-1 Levels of Significant Exposure to 1,3-butadiene - Inhalation (continued) a

Key to Species

Figure (Strain) Exposure/

Duration/

Frequency

(Route) System NOAEL (ppm) Less Serious (ppm) LOAEL

Serious

(ppm) Reference

Chemical Form

Comments

Developmental

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INTERMEDIATE EXPOSURE Death

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Exposure/

LOAEL

Duration/ a Key to Species

Figure (Strain) Frequency

(Route) System NOAEL (ppm) Less Serious (ppm) Serious (ppm)

Systemic

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,URQVHWDODE Table 3-1 Levels of Significant Exposure to 1,3-butadiene - Inhalation (continued)

Exposure/

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(ppm) (ppm) Chemical Form Comments

173

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LOAEL

Duration/ a Key to Species Frequency NOAEL Less Serious Serious Reference (Route)Figure (Strain) System (ppm) (ppm) (ppm) Chemical Form Comments 18 ZN KUG GZN5HVS00DOYHRODUHSLWKHOLDO

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Key to Species

Figure (Strain)

22

Reproductive

23
24
25

Cancer

26

Exposure/

Duration/

Frequency

(Route) System NOAEL (ppm) Less Serious (ppm) LOAEL

Serious

(ppm) Reference

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Comments



173

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Key to

Figure Species

(Strain) Exposure/

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(Route) System NOAEL (ppm) Less Serious (ppm) LOAEL

Serious

(ppm) Reference

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CHRONIC EXPOSURE Death

27
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Table 3-1 Levels of Significant Exposure to 1,3-butadiene - Inhalation (continued)

Exposure/

LOAEL

Duration/ a Key to Species Frequency NOAEL Less Serious Serious Reference (Route)Figure (Strain) System (ppm) (ppm) (ppm) Chemical Form Comments 31
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Key to Species

Figure (Strain)

33

Neurological

34
35

Reproductive

36
37
38
39

Exposure/

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3.2.1.3 Immunological and Lymphoreticular Effects

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