[PDF] facteur vii

Is factor VII a recombinant gene?

Factor VII shares a common domain architecture with factors IX and X . The gene for factor VII is located on chromosome 13 (13q34). Factor VII deficiency (congenital proconvertin deficiency) is rare and inherited recessively. It presents as a hemophilia-like bleeding disorder. It is treated with recombinant factor VIIa (NovoSeven or AryoSeven ).

Is factor VII deficiency a life threatening condition?

Severely affected individuals have an increased risk of bleeding inside the skull (intracranial hemorrhage) or in the gastrointestinal tract, which can be life-threatening. Although factor VII deficiency is primarily associated with increased bleeding, some people with the condition have excessive blood clotting (thrombosis).

How is inherited factor VII deficiency diagnosed?

Inherited Factor VII deficiency is usually diagnosed with a laboratory workup performed after a bleeding episode or during familial screening in cases with a known history of the disease. Factor VII deficiency can also be a serendipitous finding.

How is FVII activated?

Once bound to TF, FVII is activated to FVIIa by different proteases, among which are thrombin (factor IIa), factor Xa, IXa, XIIa, and the FVIIa-TF complex itself. The complex of factor VIIa with TF catalyzes the conversion of factor IX and factor X into the active proteases, factor IXa and factor Xa, respectively.