Alcohols Phenols and Ethers
You may also visualise ethers as compounds formed by. 2022-23. Page 2. 324. Chemistry substituting the hydrogen atom of hydroxyl group of an alcohol or phenol
Chapter 3 Alcohols Phenols
https://www.angelo.edu/faculty/kboudrea/index_2353/Chapter_03_2SPP.pdf
Guideline for Disinfection and Sterilization in Healthcare Facilities
technology (based on tests of inoculated carriers in lab setting) . level disinfectants (i.e. phenolic
Lab 14: Qualitative Organic Analysis
alcohols & aldehydes. 2
Laboratory Exercises in Microbiology: Discovering the Unseen
students can answer the questions based on what they observe in the lab rather than on prior preparation. A copy of this exercise as well as answers to
Disinfection 101
time needed to kill versus inactivate microorganisms. For example 70% isopropyl alcohol can destroy Mycobacterium tuberculosis in 5 minutes
Chapter 5 Carboxylic Acids and Esters
23 para-Aminobenzoic aid (PABA). Used in sunscreens; absorbs short-wavelength UV light. carboxylic acid with an alcohol or phenol (plus an.
The Handbook - Laboratory Diagnosis of Tuberculosis by Sputum
TB Laboratory Register for smear and Xpert MTB/RIF. Lab. introduction Page 23 ... if your skin is contaminated with phenol bleach or alcohol
Laboratory Solution Preparation
Volume percent solutions are defined as milliliters of solute per. 100 mL of solution. Example: 10 mL of ethyl alcohol plus 90 mL of H2O (making approx. 100 mL
Laboratory Procedure Manual
All used. Page 4 of 23. Page 5. Total Cholesterol Direct HDL
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Accessible version: https://www.cdc.gov/infectioncontrol/guidelines/disinfection/Guideline for Disinfection and
Sterilization in
Healthcare
Facilities
, 2008Update: May 2019
William A. Rutala, Ph.D., M.P.H.
1,2 , David J. Weber, M.D., M.P.H. 1,2 , and the HealthcareInfection Control Practices Advisory Committee
(HICPAC) 3 1Hospital Epidemiology
University of North Carolina Health Care System
Chapel Hill, NC
275142
Division of Infectious Diseases
University of North Carolina School of Medicine
Chapel Hill, NC 27599-7030
Guideline for Disinfection and Sterilization in Healthcare Facilities (2008)Last update:
May 2019 2 of 163
3HICPAC Members
Robert A. Weinstein, MD (Chair)
Cook County Hospital
Chicago, IL
Jane D. Siegel, MD (Co-Chair)
University of Texas Southwestern Medical Center
Dallas, TX
Michele L. Pearson, MD (Executive Secretary)
Centers for Disease Control and Prevention
Atlanta, GA
Raymond Y.W. Chinn, MD
Sharp Memorial Hospital
San Diego, CA
Alfred DeMaria, Jr,
MDMassachusetts Department of Public Health
Jamaica Plain, MA
James T. Lee, MD, PhD
University of Minnesota
Minneapolis, MN
William A. Rutala, PhD, MPH
University of North Carolina Health Care System
Chapel Hill, NC
William E. Scheckler, MD
University of Wisconsin
Madison, WI
Beth H. Stover, RN
Kosair Children's Hospital
Louisville, KY
Marjorie A. Underwood, RN, BSN CIC
Mt. Diablo Medical Center
Concord, CA
This guideline discusses use of products by
healthcare personnel in healthcare settings such as hospitals, ambulatory care and home care; the recommendations are not intended for consumer use of the products discussed. Guideline for Disinfection and Sterilization in Healthcare Facilities (2008)Last update:
May 2019 3 of 163
Table of Contents
Executive Summary ...................................................................................................................................... 8
Introduction.................................................................................................................................................... 9
Methods......................................................................................................................................................... 9
Definition of Terms ........................................................................................................................................ 9
A Rational Approach to Disinfection and Sterilization ................................................................................. 11
Critical Items ......................................................................................................................................... 11
Semicritical Items.................................................................................................................................. 11
Noncritical Items ................................................................................................................................... 12
Changes in Disinfection and Sterilization Since 1981 .......................................................................... 13
Disinfection of Healthcare Equipment ......................................................................................................... 14
Concerns about Implementing the Spaulding Scheme ........................................................................ 14
Reprocessing of Endoscopes ............................................................................................................... 14
Laparoscopes and Arthroscopes .......................................................................................................... 18
Tonomete
rs, Cervical Diaphragm Fitting Rings, Cryosurgical Instruments, and EndocavitaryProbes ....................................................................................................................................... 19
Dental Instruments................................................................................................................................ 21
Disinfection of HBV-, HCV-, HIV- or TB-Contaminated Devices .......................................................... 22
Disinfection in the Hemodialysis Unit ................................................................................................... 22
Inactivation of
Clostridium difficile ........................................................................................................ 23
OSHA Bloodborne Pathogen Standard ................................................................................................ 24
Emerging Pathogens (Cryptosporidium, Helicobacter pylori, Escherichia coli O157:H7, Rotavirus, Human Papilloma Virus, Norovirus, Severe Acute Respiratory Syndrome[SARS] Coronavirus) ................................................................................................................. 24
Inactivation of Bioterrorist Agents ......................................................................................................... 26
Toxicological, Environmental and Occupational Concerns .................................................................. 27
Disinfection in Ambulatory Care, Home Care, and the Home .............................................................. 28
Susceptibility of Antibiotic-Resistant Bacteria to Disinfectants ............................................................. 29
Surface Disinfection .............................................................................................................................. 30
Air Disinfection ...................................................................................................................................... 32
Microbial Contaminatio
n of Disinfectants ............................................................................................. 33
Factors Affecting the Efficacy of Disinfection and Sterilization .................................................................. 34
Number and Location of Microorganisms ............................................................................................. 34
Innate Resistance of Microorganisms .................................................................................................. 34
Concentration and Potency of Disinfectants ........................................................................................ 35
Physical and Chemical Factors ............................................................................................................ 35
Organic and Inorganic Matter ............................................................................................................... 35
Duration o
f Exposure ............................................................................................................................ 35
Biofilms ................................................................................................................................................. 36
Cleaning ...................................................................................................................................................... 37
Disinfection .................................................................................................................................................. 39
Chemical Disinfectants ......................................................................................................................... 39
Alcohol............................................................................................................................................ 39
Overview. ................................................................................................................................. 39
Mode of Action. ........................................................................................................................ 39
Microbicidal Activity. ................................................................................................................ 39
Uses. ........................................................................................................................................ 40
Chlorine and Chlorine Compounds ................................................................................................ 40
Overview. ................................................................................................................................. 40
Mode of Action. ........................................................................................................................ 42
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Microbicidal Activity. ................................................................................................................ 42
Uses. ........................................................................................................................................ 42
Formaldehyde ................................................................................................................................ 43
Overview. ................................................................................................................................. 43
Mode of Action. ........................................................................................................................ 44
Microbicidal Activity. ................................................................................................................ 44
Uses. ........................................................................................................................................ 44
Glutaraldehyde ............................................................................................................................... 44
Overview. ................................................................................................................................. 44
Mode of Action. ........................................................................................................................ 45
Microbicidal Activity. ................................................................................................................ 45
Uses. ........................................................................................................................................ 46
Hydrogen Peroxide ........................................................................................................................ 47
Overview. ................................................................................................................................. 47
Mode of Action. ........................................................................................................................ 47
Microbicidal Activity. ................................................................................................................ 47
Uses. ........................................................................................................................................ 48
Iodophors ....................................................................................................................................... 48
Overview. ................................................................................................................................. 48
Mode of Action. ........................................................................................................................ 49
Microbicidal Activity. ................................................................................................................ 49
Uses. ........................................................................................................................................ 49
Ortho-phthalaldehyde (OPA) ......................................................................................................... 49
Overview. ................................................................................................................................. 49
Mode of Action. ........................................................................................................................ 49
Microbicidal Activity. ................................................................................................................ 49
Uses. ........................................................................................................................................ 50
Peracetic Acid ................................................................................................................................ 51
Overview. ................................................................................................................................. 51
Mode of Action. ........................................................................................................................ 51
Microbicidal Activity. ................................................................................................................ 51
Uses. ........................................................................................................................................ 51
Peracetic Acid and Hydrogen Peroxide ......................................................................................... 51
Overview. ................................................................................................................................. 51
Microbicidal Activity. ................................................................................................................ 51
Uses. ........................................................................................................................................ 52
Phenolics ........................................................................................................................................ 52
Overview. ................................................................................................................................. 52
Mode of Action. ........................................................................................................................ 52
Microbicidal Activity. ................................................................................................................ 52
Uses. ........................................................................................................................................ 52
Quaternary Ammonium Compounds ............................................................................................. 53
Overview. ................................................................................................................................. 53
Mode of Action. ........................................................................................................................ 53
Microbicidal Activity. ................................................................................................................ 53
Uses. ........................................................................................................................................ 54
Miscellaneous Inactivating Agents ....................................................................................................... 55
Other Germicides ........................................................................................................................... 55
Metals as Microbicides ................................................................................................................... 55
Ultraviolet Radiation (UV)............................................................................................................... 55
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Pasteurization ................................................................................................................................ 56
Flushing
- and Washer-Disinfectors ................................................................................................ 56
The Regulatory Framework for Disinfectants and Sterilants ................................................................ 57
EPA and FDA ................................................................................................................................. 57
CDC................................................................................................................................................ 57
Test Methods ................................................................................................................................. 58
Neutralization of Germicides ................................................................................................... 58
Sterilization .................................................................................................................................................. 59
Steam Sterilization ................................................................................................................................ 59
Overview. ....................................................................................................................................... 59
Microbicidal Activity. ....................................................................................................................... 61
Mode of Action. .............................................................................................................................. 61
Uses. .............................................................................................................................................. 61
Flash Sterilization ................................................................................................................................. 61
Overview. ....................................................................................................................................... 61
Uses. .............................................................................................................................................. 62
Low-Temperature Sterilization Technologies ....................................................................................... 62
Ethylene Oxide "Gas" Sterilization ....................................................................................................... 63
Overview. ....................................................................................................................................... 63
Mode of Action. .............................................................................................................................. 64
Microbicidal Activity. ....................................................................................................................... 64
Uses. .............................................................................................................................................. 64
Hydrogen Peroxide Gas Plasma
.......................................................................................................... 64
Overview. ....................................................................................................................................... 64
Mode of Action. .............................................................................................................................. 65
Microbicidal Activity. ....................................................................................................................... 65
Uses. .............................................................................................................................................. 65
Peracetic Acid Sterilization ................................................................................................................... 65
Overview. ....................................................................................................................................... 65
Mode of Action. .............................................................................................................................. 66
Microbicidal Activity. ....................................................................................................................... 66
Uses. .............................................................................................................................................. 66
Microbicidal Activity of Low-Temperature Sterilization Technologies .................................................. 67
Bioburden of Surgical Devices ............................................................................................................. 68
Effect of Cleaning on Sterilization Efficacy ........................................................................................... 69
Other Sterilization Methods .................................................................................................................. 69
Ionizing Radiation. .......................................................................................................................... 69
Dry-Heat Sterilizers. ....................................................................................................................... 69
Liquid Chemicals. ........................................................................................................................... 70
Performic Acid. ............................................................................................................................... 70
Filtration. ........................................................................................................................................ 70
Microwave. ..................................................................................................................................... 71
Glass Bead "Sterilizer". .................................................................................................................. 71
Vaporized Hydrogen Peroxide (VHP). ........................................................................................ 71
Ozone. ............................................................................................................................................ 72
Formaldehyde Steam. .................................................................................................................... 72
Gaseous chlorine dioxide. .............................................................................................................. 73
Vaporized Peracetic Acid. .............................................................................................................. 73
Infrared rad
iation. ........................................................................................................................... 73
Sterilizing Practices .............................................................................................................................. 73
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Overview. ....................................................................................................................................... 73
Sterilization Cycle Verification. ....................................................................................................... 74
Physical Facilities. .......................................................................................................................... 74
Cleaning. ........................................................................................................................................ 74
Packaging. ..................................................................................................................................... 75
Loading. ......................................................................................................................................... 76
Storage. .......................................................................................................................................... 76
Monitoring. ..................................................................................................................................... 77
Reuse of Single
-Use Medical Devices ........................................................................................................ 81
Conclusion................................................................................................................................................... 82
Web-Based Disinfection and Sterilization Resources ................................................................................. 83
Recommendations for Disinfection and Sterilization in Healthcare Facilities ............................................. 84
A. Rationale
.......................................................................................................................................... 84
B. Rankings .......................................................................................................................................... 84
New Categorization Scheme for Updated Recommendations [November 2018] ................... 84C. Recommendations ........................................................................................................................... 84
1. Occupational Health and Exposure ......................................................................................... 84
2. Cleaning of Patient-Care Devices ........................................................................................... 85
3. Indications for Sterilization, High-Level Disinfection, and Low-Level Disinfection .................. 85
4. Selection and Use of Low-Level Disinfectants for Noncritical Patient-Care Devices .............. 85
5. Cleaning and Disinfecting Environmental Surfaces in Healthcare Facilities ........................... 86
6. Disinfectant Fogging ................................................................................................................ 87
7. High-Level Disinfection of Endoscopes ................................................................................... 88
8. Management of Equipment and Surfaces in Dentistry ............................................................ 91
9. Processing Patient-Care Equipment Contaminated with Bloodborne Pathogens
(HBV, Hepatitis C Virus, HIV), Antibiotic-Resistant Bacteria (e.g., Vancomycin- Resistant Enterococci, Methicillin-Resistant Staphylococcus aureus, Multidrug Resistant Tuberculosis), or Emerging Pathogens (e.g., Cryptosporidium, Helicobacter pylori, Escherichia coli O157:H7, Clostridium difficile, Mycobacterium tuberculosis,Severe Acute Re
spiratory Syndrome Coronavirus), or Bioterrorist Agents ............................ 9110. Disinfection Strategies for Other Semicritical Devices ............................................................ 91
11. Disinfection by Healthcare Personnel in Ambulatory Care and Home Care ........................... 92
12. Microbial Contamination of Disinfectants ................................................................................ 92
13. Flash Sterilization .................................................................................................................... 92
14. Methods of Sterilization ........................................................................................................... 93
15. Packaging ................................................................................................................................ 93
16. Monitoring of Sterilizers ........................................................................................................... 93
17. Load Configuration. ................................................................................................................. 94
18. Storage of Sterile Items ........................................................................................................... 94
19. Quality Control ......................................................................................................................... 94
20. Reuse of Single-Use Medical Devices .................................................................................... 95
Performance Indicators ............................................................................................................................... 96
Acknowledgements ..................................................................................................................................... 97
Glossary ...................................................................................................................................................... 98
Tables and Figure ..................................................................................................................................... 106
Table 1. Methods of sterilization and disinfection ............................................................................... 106
Table 1A. Smooth, Hard Surface
1,4 .............................................................................................. 106Table 1B. Rubber tubing and catheters
3,4 .................................................................................... 107Table 1C. Polyethylene tubing and catheters
3,4,7 ......................................................................... 108Table 1D. Lensed instruments
4.................................................................................................... 109
Guideline for Disinfection and Sterilization in Healthcare Facilities (2008)Last update:
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Table 1E. Thermometers (Oral and Rectal)
8 ............................................................................... 110Table 1F. Hinged Instruments
4.................................................................................................... 111
Table 2. Properties of an ideal disinfectant ........................................................................................ 113
Table 3. Epidemiologic evidence associated with the use of surface disinfectants ordetergents on noncritical environmental surfaces................................................................... 114
Figure 1. Decreasing order of resistance of microorganisms to disinfection and sterilization (with thedisinfection levels indicated) ..................................................................................... 115
Table 4. Comparison of the characteristics of selected chemicals used as high -leveldisinfectants or chemical Sterilants ......................................................................................... 116
Table 5. Summary of advantages and disadvantages of chemical agents used as chemical sterilants 1or as high-level disinfectants .................................................................................. 117
Table 6. Summary of advantages and disadvantages of commonly used sterilizationtechnologies ............................................................................................................................ 118
Table 7. Minimum cycle times for steam sterilization cycles .............................................................. 119
Table 8. Examples of flash steam sterilization parameters ................................................................ 120
Table 9. Characteristics of an ideal low-temperature sterilization process ........................................ 121
Table 10. Factors affecting the efficacy of sterilization....................................................................... 122
Table 11. Comparative evaluation of
the microbicidal activity of low-temperature sterilizationtechnology (based on tests of inoculated carriers in lab setting) ............................................ 123
Table 12. Suggested protocol for management of positive biological indicator in a steamsterilizer ................................................................................................................................... 124
Disclosure of Financial Interests and
Relationships (2000
- July 2004) ................................................... 124References ................................................................................................................................................ 125
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Executive Summary
The Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008, presents evidence-based recommendations on the preferred methods for cleaning, disinfection and sterilization of patient-
care medical devices and for cleaning and disinfecting the healthcare environment. This document supercedes the relevant sections contained in the 1985 Centers for Disease Control (CDC) Guideline forHandwashing and Environmental Control.
1 Because maximum effectiveness from disinfection andsterilization results from first cleaning and removing organic and inorganic materials, this document also
reviews cleaning methods. The chemical disinfectants discussed for patient-care equipment include alcohols, glutaraldehyde, formaldehyde, hydrogen peroxide, iodophors, ortho -phthalaldehyde, peracetic acid, phenolics, quaternary ammonium compounds, and chlorine. The choice of disinfectant, concentration, and expo sure time is based on the risk for infection associated with use of the equipment and other factors discussed in this guideline. The sterilization methods discussed include steam sterilization, ethylene oxide (ETO), hydrogen peroxide gas plasma, and liquid peracetic acid. Whenproperly used, these cleaning, disinfection, and sterilization processes can reduce the risk for infection
associated with use of invasive and noninvasive medical and surgical devices. However, for these processes to be effective, hea lth-care workers should adhere strictly to the cleaning, disinfection, and sterilization recommendations in this document and to instructions on product labels. In addition to updated recommendations, new topics addressed in this guideline include1. inactivation of antibiotic-resistant bacteria, bioterrorist agents, emerging pathogens, and
bloodborne pathogens;2. toxicologic, environmental, and occupational concerns associated with disinfection and
sterilization practices;3. disinfection of patient-care equipment used in ambulatory settings and home care;
4. new sterilization processes, such as hydrogen peroxide gas plasma and liquid peracetic acid; and
5. disinfection of complex medical instruments (e.g., endoscopes).
Guideline for Disinfection and Sterilization in Healthcare Facilities (2008)Last update:
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Introduction
In the United States, approximately 46.5 million surgical procedures and even more invasive medicalprocedures - including approximately 5 million gastrointestinal endoscopies - are performed each year.
2Each procedure involves contact by a medical device or surgical instrument with a patient's sterile tissue
or mucous membranes. A major risk of all such procedures is the introduction of pathogens that can lead
to infection. Failure to properly disinfect or sterilize equipment carriesquotesdbs_dbs8.pdfusesText_14[PDF] alcohols are characterized by which type of functional group
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