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iRemerciements
ses suggestions utiles durant toutes les années de thèse, pour sa disponibilité constante durant cette période, pour ses encouragements dans les moments difficiles. Je veux laremercier pour sa contribution précieuse à mon travail et son aide. Elle a cru en moi. Sans elle,
finir ma thèse aurait été impossible. Je tiens à remercier Claire Auplat, Jean-Yves Bottero, Albert David, Sylvie Lupton, Pascal Lerapports préliminaires très intéressants et encourageants. Je remercie également tous les
recherche. Je veux remercier également le jury de pré-soutenance, particulièrement Albert David et Leur expérience et mode de réflexion sont pour beaucoup dans la progression etCette thèse est réalisée au sein du Labex SERENADE, dans l'équipe M-Lab du laboratoire DRM
Damart, Emilie Canet, Pierre-Emmanuel Arduin, Mustapha Sali, Béatrice Parguel et Doudja de source de données, et son temps consacré. Je remercie Laurence Rouïl pour son soutien et sa participation dans le comité de suivi de ma ii donné des pistes de réflexions intéressantes, le temps consacré et ses commentaires pour mon travail. De plus, je veux remercier mon tuteur scientifique, Pierre Boucard, pour nos certains sujets et certaines de mes idées. Merci à Simone Schucht pour les corrections de mes papiers de conférence, son aide pour la recherche des données et son soutien moral important. Je remercie Laure Malherbe, Maxime Beauchamp et Vincent Lemaire pour leur disponibilité et leur aide pour la clarification de points particuliers. Je remercie aussi tous les experts du domaine des nanotechnologies et du bisphénol A, interviewés et le temps passé pour avoir rempli mon questionnaire. particulièrement, Vincent Lemaire, Yasmine Saleh, Carmen Cantuarias, Cristiane Stainsack- Brau, Arianna Oddo, Matt Fuller et Jovana Kovacevic. Je remercie Françoise Carbon, Jessica Lafeuille et Florence D'Alexis pour leur aide dans lesorganisateurs des conférences et les participants, pour cette expérience et les valeurs
ajoutées de réflexion, les questions et commentaires reçus qui ont contribué à mes réflexions.
En particulier, merci à Michael Dietrich et Francesco Quatraro pour leurs suggestions intéressantes. iii ouvert un autre côté de la vérité de la vie de la thésarde. Je remercie mes parents pour leur compréhension, soutien, affection et compréhension et aide. Merci à mon mari : tu fais ma vie meilleure jour après jour. Je souhaiterais remerciermon grand-père pour son attitude, son esprit, sa vitalité et sa bonté. Il aime la vie autour de
We gratefully acknowledge that this research is funded by the French National Research Council (ANR) LABEX research grant: SERENADE 11-LABX-0064, coordinated by A*MIDEX ANR-11-IDEX-0001.
vTable of Contents
Chapter 1. Background of the thesis ....................................................................................................... 1
1.1. Introduction .................................................................................................................................. 1
1.2. Thesis outline ............................................................................................................................. 13
Chapter 2. Literature review ................................................................................................................. 17
2.1. Definition of innovation ............................................................................................................. 18
2.2. Theoretical perspectives on diffusion of innovation .................................................................. 19
2.2.1. Sociological perspective on diffusion of innovation............................................................ 19
2.2.2. Overview of the Bass model ................................................................................................ 26
2.2.3. Managerial perspective on adoption/rejection of innovation ............................................ 28
2.2.4. Epidemic, rank, order and stock effect models ................................................................... 30
2.3. Literature on international diffusion .......................................................................................... 32
2.3.1. Factors influencing diffusion of innovation at international level ...................................... 33
2.3.2. Key drivers at different stages of the product life cycle at international level ................... 38
2.4. Negative information in Marketing ............................................................................................ 50
2.5. Diffusion of innovation in a situation of uncertainty about environmental and health risks: what
does the literature say? ..................................................................................................................... 51
2.6. Uncertainty about environmental and health risks and new scientific knowledge ................... 54
2.6.1. The nature of uncertainty ................................................................................................... 54
2.6.2. Risk management principles ............................................................................................... 56
2.6.3. The precautionary principle (PP) ......................................................................................... 57
2.6.4. Different interpretations of PP ............................................................................................ 59
2.6.5. Models for the governance of innovation and risk ............................................................. 63
2.6.6. A model of impact for unfortunate events ......................................................................... 66
2.6.7. Information dissemination .................................................................................................. 69
2.6.8. Disagreement between experts and the public (hazard and outrage) ............................... 70
2.6.9. Cultural contexts ................................................................................................................. 71
vi2.6.10. Conceptive research .......................................................................................................... 73
Chapter 3. Research design and methodology ..................................................................................... 77
3.1. Hypothesis (our main hypothesis) .............................................................................................. 78
3.2. Research approach and epistemological positioning ................................................................. 86
3.3. Data sources and measures for our dependent variables (quantitative studies) ...................... 87
3.4. Conceptual model ...................................................................................................................... 89
3.5. Methods of data analysis (quantitative studies) ........................................................................ 91
3.6. Qualitative study ........................................................................................................................ 93
Chapter 4. Evolution of nanosilver and BPA industries ......................................................................... 99
4.2. Descriptive comparison between the history of BPA and the beginning of history of nanosilver
......................................................................................................................................................... 102
4.2.1. General facts ..................................................................................................................... 102
4.2.2. The regulatory framework ................................................................................................ 109
4.2.3. Responsible development ................................................................................................. 121
4.3.1. Industry self-regulation and voluntary reporting schemes ............................................... 126
4.3.2. Other reactions to new scientific knowledge .................................................................... 128
4.4. NGOs and their activities related to new scientific knowledge ............................................... 130
Chapter 5. Bisphenol A: background information and publications in scientific journals .................. 137
5.1. Research questions .................................................................................................................. 138
5.2. Data collection .......................................................................................................................... 139
5.3. Bisphenol A use ........................................................................................................................ 142
5.4. Bisphenol A in the value chain ................................................................................................. 143
5.5. Bisphenol A: health and environmental concerns ................................................................... 144
5.6. BPA consumption pattern ........................................................................................................ 146
5.7. New scientific knowledge: variable construction .................................................................... 147
Chapter 6. Bisphenol A consumption, economic growth and new scientific knowledge about risk .. 153 vii6.1. Background information on the Environmental Kuznets Curve............................................... 154
6.2. Hypotheses: impact of economic growth and other factors on BPA consumption ................. 157
..................................................................................................................................................... 157
6.3. Hypotheses: under- and over-consumption of bisphenol A .................................................... 160
6.4. Methodology: bisphenol A modeling ....................................................................................... 162
6.4.1. Reduced form model ......................................................................................................... 163
6.4.2. Extended form model ........................................................................................................ 166
6.4.3. Over- and under-consumption of bisphenol A .................................................................. 168
6.4.4. Policy analysis .................................................................................................................... 169
6.4.5. Data sources ...................................................................................................................... 170
6.5 Results ....................................................................................................................................... 176
6.5.1. Reduced form model ......................................................................................................... 176
6.5.2. Extended form model: additional predictors selection (principal component analysis) .. 177
6.5.3. Over- and under-consumption of bisphenol A: test for endogeneity ............................... 188
6.5.4. Policy analysis .................................................................................................................... 192
6.5.5. Alternative measures of scientific knowledge .................................................................. 195
6.7. Conclusions ............................................................................................................................... 196
Chapter 7. Assessing the influence of economic growth and new scientific knowledge about risk onpolycarbonate consumption in Japan ................................................................................................. 199
7.1. Data and methodology ............................................................................................................. 200
7.1.1. Data ................................................................................................................................... 200
7.1.2. Methodology ..................................................................................................................... 206
7.2. Estimation results ..................................................................................................................... 211
7.3. Conclusions ............................................................................................................................... 224
Chapter 8. Results and discussion ....................................................................................................... 229
8.1. Main results .............................................................................................................................. 229
8.1.1. Question 1. What are the key determinants of international uptake of innovation in a
situation of uncertainty about environmental and health risks?................................................ 229
viii8.1.2. Question 2. Does the number of risk-related scientific publications impact consumption?
..................................................................................................................................................... 234
8.1.3. Link to the industry life cycle ............................................................................................. 238
8.2. Similarities between bisphenol A and nanosilver .................................................................... 242
8.2.1. Time sequences of diffusion of scientific knowledge related to environmental and health
risks and sources of uncertainty about environmental and health risk of nanosilver and bisphenolA ................................................................................................................................................... 243
8.2.2. Bisphenol A and nanosilver in the value chains ................................................................ 246
8.2.3. Similarities in the perceived psychological distance ......................................................... 248
8.3. Comparison of sequences of events in the history of BPA and the beginning of history of
nanotechnology (interpretation of results) .................................................................................... 250
8.3.1. Question 3. What is the link between new scientific knowledge and different stakeholders
in a situation of uncertainty about environmental and health risks? ......................................... 250
8.3.2. Activities in response to new scientific knowledge ........................................................... 256
8.3.3. Prescriber in the relationship between an intermediate good and consumers ............... 257
8.3.4. Change levers, new scientific knowledge and consumption ............................................ 261
8.3.5. Disruptive innovation ........................................................................................................ 262
Chapter 9. Conclusions, directions for future investigations and contributions ................................ 265
9.1. Conclusions ............................................................................................................................... 265
9.2. Limitations and further research .............................................................................................. 268
9.2.1. Limitations ......................................................................................................................... 268
9.2.2. Sociological ballistics ......................................................................................................... 269
9.2.3. Threshold models of collective behavior .......................................................................... 271
9.3. Theoretical and methodological contributions, implications for nanosilver and limitations .. 272
9.3.1. Theoretical contribution .................................................................................................... 272
9.3.2. Methodological contributions ........................................................................................... 275
References ........................................................................................................................................... 277
Appendix A. Bass model and its extensions ........................................................................................ 297
Appendix B. Questionnaire ................................................................................................................. 301
ixAppendix C. Turning points: slowdown and the beginning of decline, by entity ................................ 303
Appendix D. List of contacts ................................................................................................................ 309
Appendix E. Questionnaire about new scientific knowledge and responses ..................................... 311
Appendix F. The list of entities used in the analysis ............................................................................ 323
Appendix G. Bisphenol A consumption ............................................................................................... 325
Appendix H. Polycarbonate sales value .............................................................................................. 337
Appendix I. Mission statement ............................................................................................................ 341
List of Abbreviations ............................................................................................................................ 347
List of Tables ........................................................................................................................................ 353
List of Figures ....................................................................................................................................... 357
Contexte de la thèse ........................................................................................................................ 363
Introduction ................................................................................................................................. 363
Plan de la thèse ........................................................................................................................... 375
Conclusions principales ................................................................................................................... 378
1Chapter 1. Background of the thesis
Recent advances in analytical and imaging technologies made it possible to manufacture nanomaterials which have led to nanotechnology innovations (Mark R. Wiesner, Lowry, Alvarez, Dionysiou, & Biswas, 2006). Nowadays the physical and chemical properties of nanoparticles can be controlled and adapted for particular applications (Mark R. Wiesner & Bottero, 2007). Uncertainty about environmental and health risks that surrounds nanotechnology raises the questions of innovation success. As the market for nanotechnology expands, managerial interest in understanding the drivers of uptake of nanomaterials grows. Due in part to a lack of consistent data, there is limited empirical literature on determinants of diffusion of nanotechnology. We attempt to address the following general question about the diffusion of innovation: What are the main factors that influence the uptake of innovation in a situation of uncertainty about environmental and health risks? This chapter is organized as follows. First, it establishes the context and importance of our research. Second, we provide our main working hypothesis. Third, this chapter lists the specific research questions and it gives a brief overview of the research structure.1.1. Introduction
In 2000, the National Nanotechnology Initiative (NNI) was established by President Clinton in the United States of America (USA). The initiative was started with the goal of developing a nanotechnology research, promoting the process for conceiving of new products based on new technologies, training a highly skilled workforce, developing an infrastructure for nanotechnology and advocating responsible nano-development1. The Nanotechnology Research Directions report (IWGN, 1999) had recommended launching this initiative and1 https://www.nano.gov/about-nni/what/vision-goals, accessed in April 2017
Chapter 1. Background of the thesis
2 providing government funding in the amount of about $500 million dollars (twice as high as in1999) to support nanotechnology. With the help and support of this initiative more than $23
billion have been invested in nanotechnology since 2001 (National Science and Technology Council Committee on Technology, 2016). In Europe, public funding has increased from Nanotechnology is funded by the European Commission through the Seventh Framework Programme (2007-2013) and Horizon 2020 (2014-2020) (European Commission, 2013). These are some examples of funding of nanotechnology research. In comparison to nanotechnology, billion3. Space research and innovation activities are funded by the European Commission through Horizon 2020 (Reillon, 2015, 2017). What is nanotechnology and why it has been included in research and innovation programs all over the world? is about 1 to 100 nanometers. Just how small is that? A nanometer is one-billionth of a meter. For reference, a sheet of paper is about 100,000 nanometers thick. Nanoscale matter can Technology Council Committee on Technology, 2016, p. 1). There is no agreed definition of nanotechnology. In 2011, the European Commission (Commission recommendation of 18 natural, incidental or manufactured material containing particles, in an unbound state or as an aggregate or as an agglomerate and where, for 50 % or more of the particles in the number size distribution, one or more external dimensions is in the size range 1 nm-100 nm. In specific cases and where warranted by concerns for the environment, health, safety or competitiveness, the number size distribution threshold of 50 % may be replaced by a nanomaterial (2011/696/EU) imposes no binding legal obligations. The discussion about a definition that can be applied to all regulatory documents is ongoing (Bernard, 2016a).2 European Union
3 https://europa.eu/european-union/topics/space_en, accessed in April 2017
3 Expected economic impact of nanotechnology is huge. Commercialization of nanotechnology Bozeman, Hardin, & Link, 2008, p. 753). The European Commission highlights the importance of key enabling technologies (KETs) which include nanotechnology to European sustainable growth and its combativeness in world markets. For example, nanotechnology is expected to benefit the following sectors: energy, health care and environment. Nanotechnology was chosen not only because of its economic potential, but also its potential societal impact, its knowledge intensity and a pervasive effect on different types of innovation. Besides, key supposed to have great potential for the exploitation and eventual transformation of the Nanotechnology innovation might help to address issues related to environmental Winans, Pasanen, Werner, & Brand, 2001). It is currently used in various areas: medicine, information technology, energy production and storage, security, food, electronics, etc (European Commission, 2004; Nowack, Krug, & Height, 2011; Pulit-Prociak & Banach, 2016). While cancer is one of the principal causes of death worldwide, a technological innovation is needed to decrease cancer mortality rates. A cancer treatment is one of the research areas of nanotechnology including a cancer diagnosis and it might offer promising solutions to this problem (Gmeiner & Ghosh, 2014). Meanwhile, several working groups on nanotechnology have been established all over the world. For example, the Organisation for Economic Co-operation and Development, OECD established the Working Party on Manufactured Nanomaterials (WPMN) in 2006. OECD prepared guidelines related to exposure to nanomaterials in laboratories and for the testing of nanomaterials over the period of 2008-2009 and published a large quantity of reports related to exposure assessment of nanomaterials in 2016. Numerous international and national workshops, conferences and summer schools related to nanotechnology are also organized all over the world to discuss health and environmental issues related to nanomaterials. Why is there so much attention surrounding health and environmental issues? Nanotechnology has become the subject of considerable debate due to uncertainty about environmental and health risks associated with the production and use of nanotechnologyChapter 1. Background of the thesis
4 innovations. This uncertainty adds to different uncertainties inherent in every innovation. The uncertainty about environmental and health risks is a consequence of a lack of knowledge on exposure and hazards level. For instance, since the early 2000s, concerns over potential risks from exposure to carbon nanotubes have been raised. Several studies have shown that the States National Institute for Occupational Safety and Health recommended an exposure limit (WHO4 Regional Office for Europe, 2013). At the present time, the exposure level to different nanomaterials is difficult to define as nanomaterials are not often indicated as components (Scientific Committee on Emerging and Newly Identified Health Risks, 2014). Besides, production data (methods, volume and capacity) is rarely disclosed (Hendren, Mesnard, be considered, for example, form and size of particles and their concentration. The occupational exposure to nanomaterials has not been completely examined. Further investigation is required to better understand genotoxicity of nanomaterials (Scientific Committee on Emerging and Newly Identified Health Risks, 2014). Previous experience with Genetically Modified Organisms (GMOs) in food suggests that these types of risk and related uncertainty may lead to the rejection of innovation (Paddock, 2010; Steenis & Fischer, 2016). Besides, some applications of nanomaterials related to food are frequently compared to genetically modified organisms in terms of societal acceptance (Gupta, Fischer, George, & Frewer, 2013)5. This short discussion on pledges and perils related to nanotechnology has led to questions on a capacity for successful diffusion of nanotechnology. What makes diffusion of nanotechnology innovation possible? An exploration of the determinants of adoption and rejection of innovation in a situation of uncertainty about environmental and health risks may help to answer this question. We will see that recent studies have identified some patterns of the diffusion of nanotechnology in a situation of uncertainty, they have not fully explored it. The literature on the diffusion of innovation studies the factors that influence the adoption and diffusion of innovation (Tidd & Bessant, 2013). A large number of different factors have4 World Health Organization
5 However, certain risks related to genetically modified corps was brought to public attention by nonexperts (Auplat, 2008)
which one of the differences between genetically modified food and nano-food. 5 been identified in the literature (we will discuss them in later chapters). It is not clear whether impact the diffusion of nanomaterials in a situation of uncertainty about environmental and health risks. Previous work on the diffusion of innovation has found, that in most cases, a cumulative number of adopters presented over time results in an S-shaped curve presented in Figure 1 (Rogers, 2003).Figure 1. S-curve
Source: Reproduced from Rogers (2003)
successful innovation which is first adopted by a few actors, which belongs to innovators category. Then, the number of adopters increases rapidly resulting in a fast rate of growth, but then it continues increasing at a decreasing rate again until the end of process (Rogers,2003). While it can be assumed that an adoption of nanotechnology follows an S-shaped curve
(Working Party on Nanotechnology Organisation for Economic Co-operation and Development, 2012), what are the reasons for successful diffusion of nanotechnology? This leads to several general questions: what factors influence the diffusion of innovation in a situation of uncertainty about environmental and health risks? What (conventional) factors have a specific influence on the uptake of an industrial good in the context? The quantity of scientific articles examining toxicity of nanomaterials such as nanosilver is constantly growing (see Figure 2). Increasing scientific evidence of potential undesirable effects of a new product might have an important effect on the rise of scientific controversyCumulative number of adoptions
TimeChapter 1. Background of the thesis
6 surrounding nanosilver and public concern. This controversy is fueled by the rapidly expanding quantity of new scientific knowledge related to risk which might lead to decrease in its (uptake) consumption. The conclusions of research papers on risk might diverge significantly. Some papers conclude that there is a potential risk to health and environment associated with nanosilver, the others conclude that there is no potential risk. Sometimes, the findings of the research are unclear (for example, if they state some effects without indicating whether they are harmful or not) or the author(s) could not reach a conclusion. The ongoing divergence of conclusions is also likely to spark more controversy. Figure 2. Number of publications: nanosilver and toxicitySource: Ostapchuk, based on PubMed
Our main working hypothesis is about new scientific knowledge about risk. Drawing upon the precautionary principle (PP) and a model of impact for unfortunate event (which are discussed in more detail in Chapter 2 and Chapter 4), we hypothesize that the increasing quantity of new scientific knowledge about risk impacts negatively the diffusion of innovation in a situation of uncertainty about environmental and health risks. The higher the quantity of scientific knowledge about risk related to a product, the lower the sales of this product. Indeed, Godard (2003) sheds light on the importance of scientific knowledge in the case of decisions under uncertainty. The quantity of scientific knowledge is one of the dimensions of plausibility. Scientific plausibility is an important element of the principle of proportionality, which is a part of the precautionary principle (Godard, 2003). The PP applies where there is a lack of scientific certainty about characterization and assessment of risks (Sunstein, 2005). The PP underpins most EU regulations. Besides, the European Commission recommends to adoptquotesdbs_dbs46.pdfusesText_46[PDF] les adjectifs de couleur exercices corrigés pdf
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