[PDF] MICROANGIOPATHIES THROMBOTIQUES

What is thrombotic microangiopathy?

Thrombotic microangiopathy ( TMA) is a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury. It may be seen in association with thrombocytopenia, anemia, purpura and kidney failure . The classic TMAs are hemolytic uremic syndrome and thrombotic thrombocytopenic purpura.

Does hypertension improve thrombotic microangiopathy?

Control of hypertension often improves thrombotic microangiopathy ( 7 ). Thrombotic microangiopathies are systemic diseases that can manifest in all vascular systems but are mainly in the central nervous system, intestine, and kidneys. A combination of thrombocytopenia and hemolysis should lead to a suspicion of thrombotic microangiopathy.

What is primary thrombotic microangiopathy (TMA) syndrome?

Primary Thrombotic Microangiopathy (TMA) Syndromes. Figure 1. Pathological Features of the Nine Primary Thrombotic Microangiopathy (TMA) Syndromes. The thrombotic microangiopathy (TMA) syndromes are extraordinarily diverse. They may be hereditary or acquired. They occur in children and adults. The onset can be sudden or gradual.

How is thrombotic microangiopathy (aHUS) diagnosed?

Diagnosis of aHUS requires exclusion of both STEC-HUS (typical HUS, with Shiga toxin detection in stool or blood) and ADAMTS13-mediated thrombotic microangiopathy (TMA) (TTP, with ADAMTS13 levels