[PDF] amine and carboxylic acid reaction mechanism

The direct reaction of a carboxylic acid with an amine would be expected to be difficult because the basic amine would deprotonate the carboxylic acid to form a highly unreactive carboxylate. However when the ammonium carboxylate salt is heated to a temperature above 100 oC water is driven off and an amide is formed.
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  • Do carboxylic acid react with amines?

    Carboxylic acids react with amines in the presence of a catalyst to form amides.
    This reaction is called amidation.
    The amide molecule has the characteristic carboxyl group (-COO-) and an amine group (-NH2) attached to the nitrogen atom.

  • What is the product of reaction of amine with carboxylic acid?

    What is product of reaction of amines with carboxylic acids?? RNH2 + CH2COOH ? R-NH-COCH3 + H2O .
    Hence formation of amides takes place.

  • What is the bond between amine and carboxylic acid?

    A peptide bond is a chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amino group of the other molecule; thereby, releasing a molecule of H2O.
    This is a dehydration synthesis reaction and usually occurs between amino acids and the resulting molecules is an amide.

  • What is the bond between amine and carboxylic acid?

    In the last step, the amide ion deprotonates the carboxylic acid to form a carboxylate salt and an amine as products.
    This final deprotonation step essentially removes the carboxylic acid from the equilibrium which drives the reaction towards completion.

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