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Acknowledgments Remerciements

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TABLE OF CONTENTS

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RESUME

16

ABSTRACT

17

RESUME LONG

18 19 20 21
22
23

PUBLICATIONS, POSTERS, PRESENTATIONS

Biomedicines

ĮNeuropathol Appl Neurobiology

Biomolecules

Cells Brain 24
25

ABBREVIATIONS

26
27

PREFACE

28
29

INTRODUCTION

30
31

A.Synucleinopathies

1. 32
33
34
35
36
37
38
39
40

2.Multiple System Atrophy

41
42
43
44
45
46

3.Dementia with Lewy Bodies

47

B.Į-Synuclein

1.Physiological structure and function

48
49
50
51

2.Į-syn

52
53
54
55
56

3.Cellular mechanisms impaired in synucleinopathies

57
58
59
60
61
62
63
64

C.Zinc and its implication in neurodegeneration

1.Function and localization of zinc

65
66
67
68

2.Cellular mechanisms altered by zinc

69
70
71
72

3.Zinc in CNS disorders

73
74
75

D.Models of synucleinopathy

76

1.In vitro models

77
78
79
80
81

2.In vivo models

82
83
84
85
86
87
88

E.Therapeutic approaches

89

1.Į-Syn targeting strategies

90
91

2.Heavy metal therapeutic strategies

92
93
94
95

OBJECTIVES

96
97

RESULTS

98
99
CHAPTER 1: EVALUATING THE EFFECTS OF INTRACEREBRAL

INJECTIONS OF MULTIPLE SYSTEM ATROPHY PATIENT-

DERIVED BRAIN EXTRACTS IN MICE AND MONKEYS

100
101

PROJECT 1

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