[PDF] Doss s ier e d e p e res e se

What is Doss/Dosr?

Abstract DosS/DosR is a two-component regulatory system in which DosS, a heme-containing sensor also known as DevS, under certain conditions undergoes autophosphorylation and then transfers the phosphate to DosR, a DNA-binding protein that controls the entry of Mycobacterium tuberculosisand other mycobacteria into a latent, dormant state.

Who is Dr Doss?

Dr. Doss graduated from the University of Baghdad College of Medicine in 1983. He works in Los Angeles, CA and 4 other locations and specializes in Ophthalmology. Dr. Doss is affiliated with White Memorial Medical Center. Based on patient feedback. Read the reviews

Are Doss and Dost autophosphorylating heme-dependent sensors?

Conclusions DosS and DosT are autophosphorylating heme-dependent sensors that, together with the DNA-binding protein DosR, control the expression of a family of genes that are essential for entry into and survival in the latent, dormant state.

What is a full-length protein structure of Doss & Dost?

The full-length protein structures of DosS and DosT incorporate two N-terminal GAF domains, termed GAF-A and GAF-B, followed by a histidine kinase domain that includes the conserved histidine residue that is phosphorylated, and finally by an ATPase domain (Figure 1).