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INDEX

6 1. Presentation

11 2. Research Structure

18 3. Main Figures of IdISSC Activity

22 4. Human Resources

24 5. Research Projects

27 6. Networks and Alliances

28 7. Economic Activity

29 8. Bibliometric Analysis

37 9. Other Scientic Activities

38 10. Technology Transfer

39 11. Scientic Dissemination Activities

CARDIOVASCULAR AREA (CV)

43 CV.1 Technology Assessment and Therapeutic

Strategies in Coronary Arteriosclerosis

51 CV.2 Cardiovascular Imaging

54 CV.4 Arrhythmia

57 CV.6 Cardiovascular Research Unit

60 CV.7 ValvularPathology and Large V essels

62 CV.8 Translational Research in Acute Myocardial

Syndromes (INTEGRA)

69 CV.10 Myocardial Regeneration Therapy

75 CV.11 Cardiovascular Risk

77 CV.12 Vascular Biology

INFLAMMATION, INFECTION,

IMMUNITY AND ALLERGY AREA (IIIA)

81 IIIA.1 Allergy

85 IIIA.2 Genetics and molecular

bases of complex diseases

89 IIIA.3 Musculoskeletal Pathology

93 IIIA.6 Research on Sexually Transmitted Diseases

and HIV

96 IIIA.7 Molecular and Epidemiological Study

of Resistant Microorganisms of Clinical Interest

99 IIIA.08 Kidney transplant

101 IIIA.09 Infectious Diseases/HIV

104 IIIA.10 Research on INA Infectious Disease

109 IIIA.11 Cell-biomaterial Interactions (BIO UCM)

NEUROSCIENCE AREA (NEC)

113 NEC.1 Clinical and Neurobiological Research

in Psychiatry and Mental Health

115 NEC.2 Advanced Research in Personality Disorders,

Aggression and Impulse Control

117 NEC.3 Psychoneuroendocrinology, Molecular

Neuroimaging and Genetics

in Neuropsychiatric Diseases

119 NEC.5 Applied Research in Neuroscience

(to: Neuromodulation and Neurorepair)

123 NEC.6 Neurological Diseases

131 NEC.7 Research group on environmental factors

in degenerative diseases

133 NEC.9 Brain Mapping

135 NEC.11 Neural Plasticity

137 NEC.12 Pharmacology on Neurosecretion (FARMASER)

139 NEC.13 Neurotransmission and Purinergic Signaling

141 NEC.14 DEDINUC. Degeneration and Differentiation

through Nucleotides

142 NEC.17 Neurobiology of Hearing

143 NEC.18 Research in Glaucoma, Retina and Visual Pathways

152 NEC.20 Neurotransmission and Neuromodulation

in the Central and Peripheral Nervous System

154 NEC.21 Pharmaceutical Innovation in Ophthalmology

156 NEC.22 Pathophysiology and INA Neurological

Therapeutics (NEURO-INA-IN)

ONCOLOGY AREA (ONC)

161 ONC.1 Clinical and Translational Research in Oncology

186 ONC.2 Cancer and Obesity

189 ONC.3 Pathological Anatomy

192 ONC.4 Cell Signaling Mechanisms during Development

and Tumor Progression

194 ONC.5 Cannabinoid Signaling in Tumor Cells

196 ONC.6 "Women" s Health Research Group"

OTHER LARGE SYSTEMS AREA (OGS)

201 OGS.1 Brain Glucose Sensors, Control of Satiety,

Obesity and Type 2 Diabetes

203 OGS.5 Sports Medicine

205 OGS.6 Diabetes and Cardiovascular

207 OGS.9 Endocrinology of Metabolic Diseases

210 OGS.10 Obesity and Vascular Risk

214 OGS.12 Clinical Pharmacology

217 OGS.13 Innovation and Surgery

222 OGS.14 Medical Physics

224 OGS.15 Aging

227 OGS.16 Diabetes Mellitus / Obesity

229 OGS.17 Biomedical Imaging Research

232 OGS.18 Health Care Research

234 OGS.19 Epidemiology and Health Services

238 OGS.20 Prevention of Occupational Hazards

240 OGS.21 Research in Urology. Cancer and New Therapies

242 OGS.22 Research in Physiotherapy

243 OGS.23 The Digestive System

246 OGS.24 Hematology

251 OGS.25 Pathology of Emergency

259 OGS.27 The Interdisciplinary Study Group

of Diabetic Foot

261 OGS.29 Socioeconomic Health Determinants

263 OGS.30 AFUSAN

265 OGS.31 Hematology: Megakaryopoiesis and Platelets

267 OGS.32 Ciencias Forenses: genética y toxicología forense

268 OGS.33 Chronobiological Molecular Mechanisms

269 OGS.34 Nuclear Physics Techniques and Instrumentation

in Biomedicine

271 Appendix I

284 Appendix II

Research is crucial for improving our ability to diagnose and treat dise ases. During 2018, IdISSC aimed at being

recognized as a procient health-research center, leveraging the talent and experience of their groups that try to deliv

er

brilliant results with scarce funding. Maintaining an active role in communication with external stakeholders, IdISSC

pursued research opportunities to advance our understanding of biology a nd disease, and to promote health. With a new decade rapidly approaching, IdISSC continued aligned with Eur ope"s research objectives. This 2020 vision offered exciting opportunities for research and its application to human health, which crystallized in near 17.86%

international grants awarded and 14 active international projects. The 717 investigators at IdISSC (56% women),

classied by the R1-R4 European ranking, struggled to broaden the imp act of research in their elds. IdISSC contributed to an increasing research literature that critically examines a variety of diseases, with the publication of 655 scientic articles, half of them with leader authorship, over a hundred in the rst deciles of their categories, and showing a gender balance. Working alongside IdISSC scientists, graduate students helped to uncover new knowledge and transform health care through their doctoral thesis, more than 30 read during 2018. The translation of discoveries to patient care is our nal goal. The collaboration of professionals with diverse expertise catalyzes research breakthroughs at IdISSC, shapes future avenues in tre atment strategies, and brings the results of research to patients. Seeking to improve the effectiveness of healthcare with 479 clinical trials that remained active in

2018, the platform SCReN headed by IdISSC promotes collaboration among e

xpert scientists to ensure the relevance of their clinical trial results, and the network RECLIP concentrates on pediatric clinical trials. In transit through hard

economic times, our professionals strive to stay at the leading edge of incorporating those investigation results to guide

tailored therapy and develop standards of practice: based on recent resu lts, IdISSC investigators provided new approaches summarized in 20 clinical practice guidelines.

In this collaborative research center, with 18 groups participating in 13 national networks such as RETICs and CIBERs in

diverse elds (ophthalmology, endocrinology, oncology...), everyone is focused on contributing to high-impact res

earch and trying to apply new discoveries to the study of human health. In developing the strategic plan in 2018, IdISSC reinforced core support units aimed at accelerating research, among

them the Biobank or the Clean Room to name a few. IdISSC is also stimulating innovation by building bridges between

our research laboratories and the academic, non-prot and private sec tors through the participation in the ITEMAS

network and the assistance of the Innovation Unit. IdISSC aims to identify resources and activities that will enable novel

applications to human health, displaying an organization with varied exp erts: biologists, analysts, clinicians, administrative staff.... IdISSC also cares for the societal implications of research. As the scop e of IdISSC research evolves, patient participation is imperative. IdISSC is committed to ensuring that research has the wid est impact possible, sharing results across

scientic communities with the seminar series that prioritized newly emerging groups, as well as with non-scientic

audiences through a range of didactic and outreach strategies such as “ The European Night of Investigators", “The Week

of Science" and “Women and Girls in Science". The implications of research advances must be shared, and IdISSC

has created an important interface between research and society with the forum “Science and Society hand by hand" celebrated for the rst time in 2018, but with a spirit of permanence Since the launch of IdISSC in 2012, research has progressed to become an essential component of medical care with far-

reaching implications for society. IdISSC multiplies efforts to improve human health and, as a highly col

laborative entity that supports cutting-edge science, helps to explore the mutable frontie rs of knowledge.

Elena Urcelay

Antonio Portolés Pérez

Director (FIB HCSC)

Elena Urcelay García

Scientic Director (IdISSC)

José Soto Bonel

President (FIB HCSC)

Scientific Report 2018 Scientific Report 2018

SCIENTIFIC REPORT2018

6

SCIENTIFIC REPORT2018

The Health Research Institute of the Hospital Clínico San Carlos in M adrid was created with the intention of promoting research and planning the scientic activity in line with the areas dened in t he strategic plan.

It consists of the following entities

Its mission is to promote and consolidate the activities of biomedical r esearch from groups within the Institute, building an organization of excellence for the generation of scientic knowledge, oriented to health care practice, and thus, improving th e citizens health through the interrelation of basic and clinical research , integration of resources, the encouraging of innovati on and internationalization, as well as the empowerment and recognition of rese archers and support staff, all underpinned by a dynam ic management, based on continuous improvement and learning. Its vision is to be an organization of scientic excellence with inte rnational visibility, conducting network research, and with a commitment to innovation and technological advance through the developme nt of a sustainable research and the promotion of gender equality and internationalization. The values of the Health Research Institute of the Hospital Clínico a re: accessibility, transparency, dedication to service and respect. Moreover, the groups of interest are the citizens, researchers, participating in stitutions, funding agencies and entities providing services.

1. Presentation

Scientific Report 2018

7

SCIENTIFIC REPORT2018

IdISSC Organizational Chart and Research Structure

Government Bodies

MANAGEMENT BODYGOVERNMENT BODIESCONSULTING BODIESOTHER BODIES

Management Body

(FIBHCSC)

SCIENTIFIC

DIRECTION BODY

Scientific Direction

Research Areas

Cardiovascular

Core Facilities: Transversal Support Units

NeuroscienceOncology

Inflammation, Infection,

Inmunity and AllergyOther Large

Systems

Executive CommitteeExternal Scientific

Committee

Research CommitteeEthical Committee

in Clinical Research

Ethical Committee

in Animal

Experimentation

Governing Council

GOVERNING COUNCIL

Manuel Molina MuñozFull position at SERMAS

Ignacio Lizasoain HernándezResearch Dean of the Universidad Complutense de Madrid (UCM) José Francisco Soto BonelManaging Director of the Hospital Clínico San Carlos Joaquín Poch Broto Member of the Department of Health Carlos Macaya Miguel Member of the Department of Health Juan Angel Jover JoverMember of the Department of Health José Luis Álvarez-Sala WaltherMember of the Department of Healthquotesdbs_dbs45.pdfusesText_45

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