[PDF] acetyl coa thioester bond

The acetyl group (indicated in blue in the structural diagram on the right) of acetyl-CoA is linked to the sulfhydryl substituent of the ?-mercaptoethylamine group. This thioester linkage is a "high energy" bond, which is particularly reactive. Hydrolysis of the thioester bond is exergonic (?31.5 kJ/mol).
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  • What is thioester bond?

    In organic chemistry, thioesters are organosulfur compounds with the molecular structure R?C(=O)?S?R'. They are analogous to carboxylate esters ( R?C(=O)?O?R') with the sulfur in the thioester replacing oxygen in the carboxylate ester, as implied by the thio- prefix.

  • What does acetyl-CoA bond with?

    In acetyl-CoA, the acetyl group bonds to coenzyme A. Coenzyme A is a molecule composed of beta-mercaptoethylamine, pantothenic acid (an essential vitamin), phosphate, and adenosine diphosphate (ADP). The coenzyme part is a transporter for the acetyl group.

  • How is thioester bond formed?

    Abstract. A unique thioester bond, formed between the side chains of neighboring C and Q residues, is present in complement components C3 and C4 and the protease inhibitor alpha 2-macroglobulin.
  • In order to participate in any metabolic process, fatty acids must first be activated. They are activated by being joined in thioester linkage (R-CO-SCoA) to the -SH group of coenzyme A. The thioester bond is a high energy bond.
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