13 nov 2018 · Causes severe skin burns and eye damage Harmful if inhaled or swallowed Material is extremely destructive to the tissue of the mucous
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[PDF] ACETIC ANHYDRIDE HAZARD SUMMARY IDENTIFICATION
DOT Number: UN 1715 DOT Hazard Class: 8 (Corrosive) 137 108-24-7
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13 nov 2018 · Causes severe skin burns and eye damage Harmful if inhaled or swallowed Material is extremely destructive to the tissue of the mucous
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23 oct 2018 · Signal Word Danger Hazard Statement H314 Causes severe skin burns and eye damage H314 Causes severe skin burns and eye damage
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Safety Data Sheet according to 29CFR1910/1200 and GHS Rev 3 Effective date : 12 22 2014 Page 1 of 8 Acetic Anhydride Created by Global Safety
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Page 1/10
Safety Data Sheet
acc. to OSHA HCSPrinting date 04/27/2022Revision date 04/27/2022
53.1.21
1 Identification
· Product identifier
Trade name: Acetic Anhydride
· Article number:400031
CAS Number:
108-24-7
EC number:
203-564-8
Index number:
607-008-00-9
Application of the substance / the mixture
This product is for research use - Not for human or veterinary diagnostic or therapeutic use.Details of the supplier of the safety data sheet
Manufacturer/Supplier:
Cayman Chemical Co.
1180 E. Ellsworth Rd.
Ann Arbor, MI 48108
USAInformation department:Product safety department
Emergency telephone number:
During normal opening times: +1 (734) 971-3335
US/CANADA: 800-424-9300
Outside US/CANADA: 703-741-5970
2 Hazard(s) identification
· Classification of the substance or mixture
d~GHS02 FlameFlam. Liq. 3 H226 Flammable liquid and vapor.
d~GHS05 Corrosion Skin Corr. 1B H314 Causes severe skin burns and eye damage. d~GHS07 (Contd. on page 2) USPage 2/10
Safety Data Sheet
acc. to OSHA HCSPrinting date 04/27/2022Revision date 04/27/2022
Trade name: Acetic Anhydride
(Contd. from page 1)53.1.21
Acute Tox. 4 H302 Harmful if swallowed.
Acute Tox. 4 H332 Harmful if inhaled.
· Label elements
GHS label elements
The substance is classified and labeled according to the Globally Harmonized System (GHS).Hazard pictograms
d~GHS02d~
GHS05d~
GHS07Signal wordDanger
Hazard-determining components of labeling:
Acetic anhydride
Hazard statements
H226 Flammable liquid and vapor.
H302+H332 Harmful if swallowed or if inhaled.
H314 Causes severe skin burns and eye damage.
Precautionary statements
P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking.P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment. P241 Use explosion-proof electrical/ventilating/lighting/equipment.P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.P260 Do not breathe dusts or mists.
P264 Wash thoroughly after handling.
P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P301+P312 If swallowed: Call a poison center/doctor if you feel unwell. P301+P330+P331 If swallowed: Rinse mouth. Do NOT induce vomiting. P303+P361+P353 If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.P310 Immediately call a poison center/doctor.
P321 Specific treatment (see on this label).
P363 Wash contaminated clothing before reuse.
P370+P378 In case of fire: Use CO2, powder or water spray to extinguish. P403+P235 Store in a well-ventilated place. Keep cool.P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/national/international regulations.Classification system:
NFPA ratings (scale 0 - 4)
320Health = 3
Fire = 2
Reactivity = 0
(Contd. on page 3) USPage 3/10
Safety Data Sheet
acc. to OSHA HCSPrinting date 04/27/2022Revision date 04/27/2022
Trade name: Acetic Anhydride
(Contd. from page 2)53.1.21
· HMIS-ratings (scale 0 - 4)
HEALTH
FIREREACTIVITY3
2 0Health = 3
Fire = 2
Reactivity = 0
Other hazards
Results of PBT and vPvB assessment
PBT:Not applicable.
vPvB:Not applicable.3 Composition/information on ingredients
· Chemical characterization: Substances
CAS No. Description
108-24-7 Acetic anhydride
Identification number(s)
EC number:203-564-8
Index number:607-008-00-9
4 First-aid measures
· Description of first aid measures
General information:
Immediately remove any clothing soiled by the product. Symptoms of poisoning may even occur after several hours; therefore medical observation for at least48 hours after the accident.
After inhalation:
Supply fresh air. If required, provide artificial respiration. Keep patient warm. Consult doctor if symptoms
persist. In case of unconsciousness place patient stably in side position for transportation. After skin contact:Immediately wash with water and soap and rinse thoroughly. After eye contact:Rinse opened eye for several minutes under running water. Then consult a doctor.After swallowing:
Immediately call a doctor.
Drink copious amounts of water and provide fresh air. Immediately call a doctor.Information for doctor:
Most important symptoms and effects, both acute and delayed May cause anemia, cough, CNS depression, drowsiness, headache, heart damage, lassitude (weakness, exhaustion), liver damage, narcosis, reproductive effects, teratogenic effects.No further relevant information available.
Indication of any immediate medical attention and special treatment neededNo further relevant information available.
5 Fire-fighting measures
· Extinguishing media
Suitable extinguishing agents:
CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
For safety reasons unsuitable extinguishing agents:Water with full jet Special hazards arising from the substance or mixture67-56-1During heating or in case of fire poisonous gases are produced.
(Contd. on page 4) USPage 4/10
Safety Data Sheet
acc. to OSHA HCSPrinting date 04/27/2022Revision date 04/27/2022
Trade name: Acetic Anhydride
(Contd. from page 3)53.1.21
· Advice for firefighters
Protective equipment:Mouth respiratory protective device.6 Accidental release measures
· Personal precautions, protective equipment and emergency proceduresMount respiratory protective device.
Wear protective equipment. Keep unprotected persons away. Environmental precautions:Do not allow to enter sewers/ surface or ground water. Methods and material for containment and cleaning up: Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).Use neutralizing agent.
Dispose contaminated material as waste according to item 13.Ensure adequate ventilation.
Reference to other sections
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.See Section 13 for disposal information.
Protective Action Criteria for Chemicals
· PAC-1:
0.5 ppm
· PAC-2:
15 ppm
· PAC-3:
100 ppm
7 Handling and storage
· Handling:
Precautions for safe handling
Ensure good ventilation/exhaustion at the workplace.Prevent formation of aerosols.
Information about protection against explosions and fires:Keep ignition sources away - Do not smoke.
Protect against electrostatic charges.
Keep respiratory protective device available.
Conditions for safe storage, including any incompatibilities Storage:Store in accordance with information listed on the product insert. Requirements to be met by storerooms and receptacles:No special requirements. Information about storage in one common storage facility:Not required. Further information about storage conditions:Keep receptacle tightly sealed. Specific end use(s)No further relevant information available.8 Exposure controls/personal protection
· Additional information about design of technical systems:No further data; see item 7. (Contd. on page 5) USPage 5/10
Safety Data Sheet
acc. to OSHA HCSPrinting date 04/27/2022Revision date 04/27/2022
Trade name: Acetic Anhydride
(Contd. from page 4)53.1.21
· Control parameters
· Components with limit values that require monitoring at the workplace:108-24-7 Acetic anhydride
PEL Long-term value: 20 mg/m³, 5 ppm
REL Ceiling limit value: 20 mg/m³, 5 ppm
TLV Short-term value: 3 ppm
Long-term value: 1 ppm
A4 Additional information:The lists that were valid during the creation were used as basis.Exposure controls
Personal protective equipment:
General protective and hygienic measures:
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.Wash hands before breaks and at the end of work.
Avoid contact with the eyes and skin.
Breathing equipment:
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer
exposure use respiratory protective device that is independent of circulating air.Protection of hands:
_SProtective glovesThe glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.Selection of the glove material on consideration of the penetration times, rates of diffusion and the
degradationMaterial of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of
quality and varies from manufacturer to manufacturer.Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has
to be observed.