Nonhomologous end-joining (NHEJ) The Rodney Dangerfield of
NHEJ evolved to repair DSBs when homologous recombination is disadvantageous NHEJ proteins act by re-annealing and joining short overhangs NHEJ yields efficient and accurate repair of DSBs End processing activities exist to deal with terminal damage - incompatible ends are a secondary phenomenon There is an inherent order to the NHEJ process
SnapShot: Nonhomologous DNA End Joining (NHEJ)
NHEJ-Specific Mechanisms Ultimately, NHEJ is a ligation reaction As with molecular cloning in vitro, this often requires preparative steps by nucleases, polymerases, and other enzymes to create ligatable ends Iterative loading of these enzymes onto the double-strand break produces the mechanistic flexibility of NHEJ (right middle panel)
Comparative analysis of NHEJ and HDR repair pathways for
Comparative analysis of NHEJ and HDR repair pathways for genomic editing using CRISPR/Cas9 technology in ES cells Astrid Jensen 1, Jeroen DeGroot 1, Uma Saha 2, Steve Festin 2, Anne- Marie Zuurmond 1 1 Charles River Leiden, Darwinweg 24, 2333 CR Leiden, Netherlands; 2 Charles River Wilmington, 251 Ballardvale Street, Wilmington MA
The non-homologous end-joining activity is required for
NHEJ ligase, LIG4, ameliorated the FA phenotype, but had no effect on BRCA1 deficiency [16] It appears the FA pathway may act to prevent inappropriate recruitment of NHEJ factors to sites of DNA damage However, the exact mechanism by which the FA pathway counteracts the NHEJ pathway is largely unknown
53BP1: pro choice in DNA repair - Titia de Lange
by c-NHEJ When this regulation fails, transloca-tions and other genome rearrangements can result, diminishing cell viability and increasing the chance of tumorigenic changes HowtheDNAdamageresponsefactor 53BP1 promotes c-NHEJ and affects the choice between HDR and c-NHEJ is the subject of this review 53BP1 engages two modified histones at
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