To determine which type of squamous cell carcinoma a patient has, a pathologist will examine a tissue sample underneath a microscope.
By identifying the type of cells that are present in a lesion, an oncologist can tailor a patient's treatment plan to achieve the best possible outcome and quality of life..
Squamous metaplastic cells are round to polygonal in shape with dense biphasic staining cytoplasm and round centrally located nuclei.
They arise from the basal layer of glandular epithelium as a protective response to stimuli, creating the transformation zone..
What does SCC look like? SCCs can appear as scaly red patches, open sores, rough, thickened or wart-like skin, or raised growths with a central depression.
At times, SCCs may crust over, itch or bleed.
The lesions most commonly arise in sun-exposed areas of the body..
Histology of SCC
Typical SCC has nests of squamous epithelial cells arising from the epidermis and extending into the dermis (figure 1).
The malignant cells are often large with abundant eosinophilic cytoplasm and a large, often vesicular, nucleus..
Histology of SCC
Typical SCC has nests of squamous epithelial cells arising from the epidermis and extending into the dermis (figure 1).
The malignant cells are often large with abundant eosinophilic cytoplasm and a large, often vesicular, nucleus..
Typical SCC has nests of squamous epithelial cells arising from the epidermis and extending into the dermis (figure 1).
The malignant cells are often large with abundant eosinophilic cytoplasm and a large, often vesicular, nucleus.
Variable keratinisation (keratinpearls etc) is present (figure 2).
Typically SCC is graded as:.
1) Well differentiated(.
Immunoperoxidase staining may be helpful in poorly differentiated and spindle cell-type SCC.
EMA, MNF116, cytokeratin5/6 and p63 are expressed in SCC.
Medical condition
Medical condition
