Cytology on pleural fluid

  • How do you preserve pleural fluid for cytology?

    If a delay is expected, the sample should be maintained at 4\xbaC until analysis, except for microbiological cultures.
    A delayed analysis of more than 48 hours is unacceptable, although the cytomorphological features of refrigerated samples are well preserved for at least 72 hours..

  • What cells are in the pleural fluid?

    The composition of normal pleural fluid consists of total white blood cell count of 1.716 x 10(3) cells mL(-1).
    Differential cell counts: 75% macrophages, 23% lymphocytes, and marginally present mesothelial cells (1% to 2%), neutrophils (1%), and eosinophils (0%)..

  • What tests are done on pleural fluid?

    A procedure called thoracentesis is performed to get a sample of pleural fluid.
    The sample is sent to a laboratory and examined under a microscope for signs of infection.
    The sample is also placed in a special dish (culture) to support the growth of microorganisms..

  • Initial pleural fluid cytology was diagnostic in 117 of 156 patients, providing a sensitivity (95% confidence interval (CI)) of 75.0% (67.4–81.6%).
    The sensitivity was 79.0% (66.8–88.3%) for lung cancer, 91.3% (72.0–98.9%) for breast cancer and 33.3% (95% CI 11.8–61.6%) for mesothelioma.Feb 21, 2022

How much pleural fluid should be sent for cytology?

How Much Pleural Fluid Should Be Sent for Cytology.
Sending at least 60 mL resulted in better sensitivity for diagnosing malignancy.
When patients with suspected malignant pleural effusion undergo diagnostic thoracentesis, what volume of fluid should be sent to the lab for cytologic diagnosis.
In this prospective study, researchers identified ..

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How The Test Is Performed

A sample of fluid from the pleural space is needed.
The sample is taken using a procedure called thoracentesis.
The procedure is done in the following way:.
1) You sit on a bed or on the edge of a chair or bed.
Your head and arms rest on a table.
2) A small area of skin on your back is cleaned.
Numbing medicine (local anesthetic) is injected in this.

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Why pleural fluid is present in lungs?

Pleural effusion, sometimes called fluid on the lung, can happen for various reasons, ranging from an infection to cancer.

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Why The Test Is Performed

A cytology exam is used to look for cancer and precancerous cells.
It may also be done for other conditions, such as identifying systemic lupus erythematosuscells.
Your doctor may order this test if you have signs of fluid buildup in the pleural space.
This condition is called pleural effusion.
The test may also be done if you have signs of lung ca.

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Will pleural effusion clear on its own?

Pleural effusion has many causes.
They include:

  1. heart failure
  2. pneumonia and other infections
  3. cancer
  4. pulmonary embolism
  5. liver disease
  6. inflammation of the tissues around the lungs

How is it treated.
A minor pleural effusion often goes away on its own without treatment.

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