Cytology of round cell liposarcoma

  • How do you identify a liposarcoma?

    Clear warning signs include: A new lump anywhere on your body, or an existing lump that grows persistently.
    Painful swelling or numbness in the area around your lump.
    Blood in your stool, or black or tarry stool (an indication of blood).

  • What are the histological features of a liposarcoma?

    The most common type of esophageal liposarcoma is the well-differentiated type, characterized histologically by mature adipocytes with a variable amount of fibrous stroma containing atypical nuclei.
    It has three main subtypes, the lipoma-like subtype, the sclerosing subtype, and the inflammatory subtype..

  • What is round cell liposarcoma?

    Myxoid/round cell liposarcoma, or MRCLS, is one of several types of liposarcoma.
    Liposarcoma is a rare cancer that grows in the cells that store fat in the body.
    MRCLS usually grows in the arms and legs.
    These tumors grow slowly, and they can spread to other parts of the body..

  • What is the hallmark of liposarcoma?

    Monovacuolated or multivacuolated lipoblasts are considered a hallmark of liposarcoma, although WDL/ALTs do not always contain lipoblasts.
    In our study, atypical lipoblasts with cytoplasmic vacuoles and scalloped nuclei were seen in some cases (Figure .

    1. D)

  • What is the most common histologic subtype of the liposarcoma?

    Well-differentiated liposarcoma (WDLPS) and dedifferentiated liposarcoma (DDLPS) are the most common histologic subtypes of LPS [Table 1].
    Together they represent 60% of all LPS and often coexist, occurring in the retroperitoneum and extremities..

  • Biopsy: To check if the tumor is LMS, your doctor will do a biopsy, taking a small sample from the tumor with a needle.
    An expert, called a pathologist, will study cells from the sample under the microscope to see what kind of tumor it is.
  • Liposarcoma are fat-producing tumours that have a spectrum of morphologies.
    Well-differentiated liposarcoma shows features similar to lipoma, with a mixture of normal-appearing adipocytes intermixed with atypical adipocytes (figures 1,2).
    The atypical cells are hyperchromatic, pleomorphic and irregular.
  • Monovacuolated or multivacuolated lipoblasts are considered a hallmark of liposarcoma, although WDL/ALTs do not always contain lipoblasts.
    In our study, atypical lipoblasts with cytoplasmic vacuoles and scalloped nuclei were seen in some cases (Figure .
    1. D)
Dec 5, 2002BACKGROUND. Round cell liposarcoma (RCL) and myxoid liposarcoma are now considered as a single pathologic entity for several reasons.AbstractMATERIALS AND METHODSRESULTSDISCUSSION
CYTOMORPHOLOGY OF MYXOID OR ROUND CELL LIPOSARCOMA: abundant granular myxoid matrix. delicate, branching, thin-walled capillaries. spindle-shaped to oval cells with occasional small cytoplasmic vacuoles.

How is liposarcoma treated?

The radiation is used to shrink the tumor so it can be removed by surgery.
Radiation therapy can also be used after surgery if there is concern that tumor cells remain after surgery.
Chemotherapy: For cases that are difficult to treat by surgery or when the cancer has spread, chemotherapy can be used to treat liposarcoma.

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What causes recurrent molecular abnormalities in liposarcoma?

Usually arise from spermatic cord; also testicular tunica; rarely epididymis Recurrent molecular abnormalities have been detected in liposarcomas, which differ between each subtype This amplification is associated with the occurrence of supernumerary ring chromosomes or giant rod chromosomes .

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What is myxoid/round cell liposarcoma (mrcls)?

Myxoid/round cell liposarcoma, or MRCLS, is one of several types of liposarcoma.
Liposarcoma is a rare cancer that grows in the cells that store fat in the body.
MRCLS usually grows in the arms and legs.
These tumors grow slowly, and they can spread to other parts of the body.
How common is MRCLS? .

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Which genes are involved in the pathogenesis of liposarcoma?

The 12q13-q15 region contains multiple genes implicated in the pathogenesis of liposarcoma, including:

  1. MDM2
  2. CDK4
  3. HMGA2
  4. TSPAN31
  5. OS1
  6. OS9
  7. CHOP
  8. STAT6 and GLI ( Virchows Arch 2010;456:277
  9. Genes Chromosomes Cancer 1999;24:30
  10. Genes Chromosomes Cancer 1995;14:8
  11. Cancer Genet Cytogenet 1997;99:14
  12. Mod Pathol 2014;27:1231 )

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