Cytology fish test

Does a positive FISH test mean bladder cancer?
Fluorescence In Situ Hybridization
The intended use is as an aid for initial diagnosis of bladder cancer in patients with hematuria and subsequent monitoring for tumor recurrence in patients previously diagnosed with bladder cancer.
Positive findings on FISH often precede visual evidence of bladder tumor..
How accurate is the FISH test for bladder cancer?
FISH is 42-83% sensitive for detecting pTa and pT1 lesions and 92-100% sensitive for pT2-4 invasive lesions in patients with known bladder cancer, while urine cytology yields sensitivities of 24-50% for pTa and pT1 lesions and 78-85% for pT2-4 invasive lesions..
How is FISH analysis performed?
To do a FISH test the pathologist needs some blood or tissue from your cancer.
This can be from a sample of tissue (biopsy), blood sample or from when you had surgery to remove your cancer.
In the laboratory, the pathologist attaches a dye and ultraviolet light to find and count the gene changes..
What does the FISH test diagnose?
One of the more common genetic tests is called the fluorescence in situ hybridization, or FISH, test.
Discovering any chromosomal changes in your cells helps doctors classify the type of cancer you have and find which drugs or treatments are most likely to s쳮d..
What is FISH analysis used for?
Fluorescence in situ hybridization (FISH) is the most convincing technique for locating the specific DNA sequences, diagnosis of genetic diseases, gene mapping, and identification of novel oncogenes or genetic aberrations contributing to various types of cancers..
Fluorescence in situ hybridization (FISH) is the most convincing technique for locating the specific DNA sequences, diagnosis of genetic diseases, gene mapping, and identification of novel oncogenes or genetic aberrations contributing to various types of cancers.
In this technique, the full set of chromosomes from an individual is affixed to a glass slide and then exposed to a “probe”—a small piece of purified DNA tagged with a fluorescent dye.
The fluorescently labeled probe finds and then binds to its matching sequence within the set of chromosomes.
The FISH test results will tell you that the cancer is either “positive” or “negative” (a result sometimes reported as “zero”) for HER2.
Generally, the FISH test is not as widely available as another method of HER2 testing, called ImmunoHistoChemistry, or IHC.
However, FISH is considered more accurate.

How a FISH test works. In FISH testing, pieces of single-strand DNA (called DNA probes) are sent to find corresponding stretches of DNA from tumor cells sampled from the body. The probes, marked with a fluorescent dye, attach to those corresponding cells—that process is called hybridization.

Is urinary cytology more sensitivity and specific than fish?

Conclusions: We found urinary cytology to be more sensitivity and specific than FISH in the detection of UC, though the difference was not statistically significant

Up to 24% of HG UCs are FISH negative due to an absence of FISH-detectable abnormalities in the tumor cells

Should cytology be combined with fish?

The combination of cytology and FISH appears to have good specificity while maintaining good sensitivity in evaluating UTUC when using modified scoring criteria for the appropriate patient population

Cancer (Cancer Cytopathol) 2014;122:459–467

What is a fish test?

FISH stands for fluorescence in situ hybridisation

It is a test that looks for gene changes in cells

Genes are made of DNA

They control everything the cell does, including when it grows and reproduces

FISH tests look for specific genes or parts of genes

If a gene change occurs, the cell may produce too much of a protein or not enough

In FISH testing, pieces of single-strand DNA (called DNA probes) are sent to find corresponding stretches of DNA from tumor cells sampled from the body. The probes, marked with a fluorescent dye, attach to those corresponding cells—that process is called hybridization.

Cytology fish test

Does a positive FISH test mean bladder cancer?

How accurate is the FISH test for bladder cancer?

How is FISH analysis performed?

What does the FISH test diagnose?

What is FISH analysis used for?

Is urinary cytology more sensitivity and specific than fish?

Should cytology be combined with fish?

What is a fish test?