Bioinformatics heart failure

  • Does genetics play a role in heart failure?

    Congestive heart failure can be passed on from generation to generation.
    Several hereditary factors put people at higher risk if their family members have congestive heart failure, such as high blood pressure, coronary artery disease, cardiomyopathy, and complications from diabetes..

  • How does genetics cause heart failure?

    Inherited genetic mutations can affect the structure of the heart muscle, which can result in symptoms of heart failure.
    Gene mutations can also affect the heart's electrical system, which might lead to abnormal heart rhythms..

  • How does genetics play a role in heart disease?

    Genetics can influence the risk for heart disease in many ways.
    Genes control every aspect of the cardiovascular system, from the strength of the blood vessels to the way cells in the heart communicate.
    A genetic variation (mutation) in a single gene can affect the likelihood of developing heart disease..

  • Is there a genetic link to heart failure?

    Congestive heart failure can be passed on from generation to generation.
    Several hereditary factors put people at higher risk if their family members have congestive heart failure, such as high blood pressure, coronary artery disease, cardiomyopathy, and complications from diabetes..

  • Is there genetic testing for heart failure?

    Genetic testing (sometimes called genomic testing) can be used to find out whether an alteration in one (or more) of your gene(s) could lead to an inherited heart condition (IHC).
    A genetic test often involves a blood test, but it can also be carried out on a sample of hair, skin or tissue..

  • What are the 4 stages of heart failure?

    Heart failure can progress, so researchers have identified four stages of the disease — A, B, C and D.
    Health care professionals also classify heart failure when it has progressed to stages C and D.
    This classification measures a patient's overall heart function and severity of symptoms..

  • What biomarkers are used to diagnose heart failure?

    Currently the natriuretic peptides are the most commonly used biomarker and help in the diagnosis and prognostication of patients with heart failure.
    Their role in the monitoring of treatment is still debatable, although it seems reasonable that patients have their natriuretic peptide values checked at discharge..

  • What biomarkers indicate heart failure?

    Currently the natriuretic peptides are the most commonly used biomarker and help in the diagnosis and prognostication of patients with heart failure..

  • What causes genetic heart failure?

    They are also referred to as genetic cardiac conditions.
    ICCs are caused by a fault – also known as a mutation – in one or more of our genes.
    If someone has a faulty gene, there's a 50/50 chance it can be passed on to your children.
    The effects of these conditions on you and your family can be enormous..

  • What gene mutations are in heart failure?

    Nearly 70% of all HCM mutations can be found in the sarcomere genes MYH7 and MYBPC3 (encoding for cardiac myosin binding protein C).
    Further common mutations are localized in TNNT2 and in the genes for troponin I (TNNI3), alpha‐tropomyosin (TPM1), or myosin light chain 3 (MYL3)..

  • What is genetic testing for heart failure?

    Genetic testing is the process of taking a sample of a person's DNA to look for changes that could cause inherited heart disease.
    Important changes in genes are called pathogenic mutations.
    The term “pathogenic” means disease-causing.
    This figure shows the genetic testing results for this family..

  • What is heart failure according to who?

    Heart failure, also known as congestive heart failure, is a condition that develops when your heart doesn't pump enough blood for your body's needs.
    This can happen if your heart can't fill up with enough blood.
    It can also happen when your heart is too weak to pump properly..

  • What is heart failure biological explanation?

    Your body depends on the heart's pumping action to deliver oxygen- and nutrient-rich blood to the body's cells.
    With heart failure, the weakened heart can't supply the cells with enough blood.
    This results in fatigue and shortness of breath, and some people experience excessive coughing..

  • What is the best scan for heart failure?

    Your doctor will check for these and other signs of heart failure.
    A test called an echocardiogram is often the best test to diagnose your heart failure.
    Your doctor can also use this test to find out why you have heart failure, and then monitor your condition going forward every three to six months..

  • What is the latest technology for heart failure?

    Multiple forms of noninvasive mobile digital technology are now available to assist in the optimal management of heart failure patients, such as teleconsultations, SMS systems, smartphone applications, wearables, and remote monitoring systems..

  • What is the new technology for heart failure?

    The Optimizer\xae Smart Mini is a minimally invasive implantable device that treats patients experiencing moderate to severe CHF symptoms even after appropriate medical treatment.
    The device operates by delivering precisely timed electric pulses called cardiac contractility modulation therapy..

  • Where does heart failure occur?

    Overview.
    Heart failure occurs when the heart muscle doesn't pump blood as well as it should.
    When this happens, blood often backs up and fluid can build up in the lungs, causing shortness of breath.
    Certain heart conditions gradually leave the heart too weak or stiff to fill and pump blood properly..

  • Who stats on heart disease?

    Cardiovascular diseases (CVDs) are the leading cause of death globally, taking an estimated 17.9 million lives each year.
    CVDs are a group of disorders of the heart and blood vessels and include coronary heart disease, cerebrovascular disease, rheumatic heart disease and other conditions..

  • About 40–50% of all HCM cases occur due to the MYBPC3 gene, the most mutated gene in HCM.
    A considerable proportion of MYBPC3-related HCM mutations are heterozygous, and people often develop the disease later in life with a benign course.
  • B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are the gold standard biomarkers used for the diagnosis of HF [27].
    In addition, BNP and NT-proBNP are the only biomarkers to date which provide additional value to the standard clinical laboratory data of HF [28].
  • Congestive heart failure can be passed on from generation to generation.
    Several hereditary factors put people at higher risk if their family members have congestive heart failure, such as high blood pressure, coronary artery disease, cardiomyopathy, and complications from diabetes.
  • Genetic testing is the process of taking a sample of a person's DNA to look for changes that could cause inherited heart disease.
    Important changes in genes are called pathogenic mutations.
    The term “pathogenic” means disease-causing.
    This figure shows the genetic testing results for this family.
  • Nearly 70% of all HCM mutations can be found in the sarcomere genes MYH7 and MYBPC3 (encoding for cardiac myosin binding protein C).
    Further common mutations are localized in TNNT2 and in the genes for troponin I (TNNI3), alpha‐tropomyosin (TPM1), or myosin light chain 3 (MYL3).
  • The heart muscle can be damaged by certain infections, heavy alcohol use, illegal drug use and some chemotherapy medicines.
    Your genes also can play a role.
    Any of the following conditions also can damage or weaken the heart and cause heart failure.
    Coronary artery disease and heart attack.
  • The Optimizer\xae Smart Mini is a minimally invasive implantable device that treats patients experiencing moderate to severe CHF symptoms even after appropriate medical treatment.
    The device operates by delivering precisely timed electric pulses called cardiac contractility modulation therapy.
The outcome of a proteomic experiment is a long list of proteins can change (or not change) due to the heart failure process. The ultimate goal is to  AbstractIntroductionTwo-dimensional gel Protein arrays
Unraveling the molecular complexities of human heart failure, particularly end-stage failure, can be achieved by combining multiple investigative approaches  AbstractIntroductionTwo-dimensional gel Protein arrays

Can bioinformatics accelerate CVD research?

While benefiting from two decades of research in bioinformatics, there remainsignificant challenges that can be addressed to accelerate CVD research.
From our own perspective, we suggest three particularly pertinent areas to prioritize cardioinformatics research:

  • data sharing/security
  • multi-omics analysis and augmented intelligence.

    • Can biomarkers be used for heart failure precision medicine?

    Heart failure (HF) is a cardiovascular disease with a high incidence around the world.
    Accumulating studies have focused on the identification of biomarkers for HF precision medicine.

    What causes heart failure (HF)?

    Furthermore, excess alcohol use, infection, cardiomyopathy of unknown causes, and coronary artery disease including:

  • previous myocardial infarction (heart attack)
  • high blood pressure
  • atrial fibrillation and valvular heart disease are common causes of HF.

    • What is a stable heart failure (CHF)?

    In the CHF, if a patient has received treatment and his or her signs and symptoms have remained generally unchanged for at least 1 month, the patient is said to have ‘Stable heart failure’.
    If chronic stable HF deteriorates, the patient may be said to be ‘Decompensated heart failure’.

    Bioinformatics heart failure
    Bioinformatics heart failure
    The Baker Heart and Diabetes Institute, commonly known as the Baker Institute, is an Australian independent medical research institute headquartered in Melbourne, Victoria.
    Established in 1926, the institute is one of Australia's oldest medical research organisations with a historical focus on cardiovascular disease.
    In 2008, it became the country's first medical research institute to target diabetes, heart disease, obesity and their complications at the basic, clinical and population health levels.
    The Baker Heart and Diabetes Institute

    The Baker Heart and Diabetes Institute

    The Baker Heart and Diabetes Institute, commonly known as the Baker Institute, is an Australian independent medical research institute headquartered in Melbourne, Victoria.
    Established in 1926, the institute is one of Australia's oldest medical research organisations with a historical focus on cardiovascular disease.
    In 2008, it became the country's first medical research institute to target diabetes, heart disease, obesity and their complications at the basic, clinical and population health levels.

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