What is Nucleoporin 62?
Nucleoporins, a family of around 30 proteins, are the main components of the nuclear pore complex in eukaryotic cells. Nucleoporin 62 is the most abundant member of this family. [2] Nucleoporins are able to transport molecules across the nuclear envelope at a very high rate.
What nucleoporins make up the nuclear pore?
Many of these nucleoporins contain a characteristic repeat sequence of phenylalanine glycine (FG) repeats. These FG-repeat nucleoporins line the central channel of the pore and provide the conduit for movement of macromolecules through the pore complex. Fig. 2. The nucleoporin proteins or Nups that make up the nuclear pore are highly conserved.
What are the functions of nucleoporins?
Nucleoporins are also involved in several cell signaling pathways that are essential for the survival, proliferation, and differentiation of cells. These include Wnt signaling, which relies on the ?-catenin repeatedly interacting with nucleoporin ( Sharma et al., 2016 ).
What can we learn from crystallography of nucleoporin subcomplexes?
Crystallography of subcomplexes of nucleoporins, as well as methods to tag single cargo molecules, importins and nucleoporins, will surely refine present models of the NPC and understanding of translocation.
Fusion entre une protéine HOX et une nucléoporine dans des