[PDF] b cell development ppt

  • What are the 4 stages of B cell development?

    First, they start as common lymphoid progenitor cells, which become early pro-B cells, then late pro-B cells, next large pre-B cells, then small pre-B cells, and finally, immature B cells. Immature B cells then migrate from the bone marrow into the lymph nodes and spleen to complete the process of maturation.

  • What is the process of B cell development?

    Introduction. B cell development starts in the bone marrow (BM) and continues in the spleen to final maturation. Developmental progression is guided by sequential events leading to assembly, expression, and signaling of the B cell antigen receptor (BCR).

  • What are the 2 main phases of B cell development?

    There are two stages in the differentiation phase: the activation of a mature naïve B cell by its specific antigen, and the generation by that cell of antigen-specific plasma cells and memory B cells.
  • B-cells work with other cells in your immune system to fight harmful invaders that can make you sick and abnormal cells, like cancer cells. Once B-cells are activated, they become plasma cells that produce antibodies in response to an antigen.
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