Serial crystallography

  • What is serial protein crystallography?

    Serial crystallography is a method for obtaining structural information on an atomic level of a protein, without the need for large protein crystals.
    Instead, small diffraction datasets are collected on many small protein crystals, which are usually easier to obtain than large ones..

  • What is Xray crystallography used for?

    X-ray crystallography is a tool used for determining the atomic and molecular structure of a crystal.
    The underlying principle is that the crystalline atoms cause a beam of X-rays to diffract into many specific directions (Fig..

  • Time-resolved serial crystallography is an emerging method to elucidate the structure-function relationship of biomolecular systems at up to atomic resolution.
Serial crystallography is an ideal method for collecting diffraction data of proteins at room temperature, where the onset of radiation damage from the X-ray beam is rapid. Serial crystallography experiment set up at Beamline ID7B2, MacCHESS.
Serial crystallography is a method for obtaining structural information on an atomic level of a protein, without the need for large protein crystals. Instead, small diffraction datasets are collected on many small protein crystals, which are usually easier to obtain than large ones.

What are the advantages of serial crystallography for time-resolved diffraction data collection?

Serial crystallography has a number of advantages for time-resolved diffraction data collection; for example, it avoids the need for reversible systems (Chapman, 2019 ▸; Weinert et al

, 2017 ▸; Schulz et al

, 2018 ▸; Mehrabi, Schulz, Agthe et al

, 2019 ▸; Mehrabi, Schulz, Dsouza et al

, 2019 ▸; Nogly et al , 2015 ▸ )

What is serial crystallography?

To that end, the technique of serial crystallography - the collection of a series of small datasets of partial completeness from many crystals- was developed

In this technique, a small dataset is collected from each crystal, and the collection of partial data is evaluated and merged together to generate a complete dataset

Serial crystallography is a method for obtaining structural information on an atomic level of a protein, without the need for large protein crystals. Instead, small diffraction datasets are collected on many small protein crystals, which are usually easier to obtain than large ones.

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