Oct 17, 2022"Atypical glandular cells (AGC)" is the term adopted by The Bethesda system of reporting cervicovaginal cytology.[1] The Bethesda reporting IntroductionIssues of ConcernAnatomical PathologyMorphology
Atypical glandular cells (AGC) diagnosis should be immediately followed up with a clinician. There is risk of premalignant lesions in patients diagnosed with AGC is as high as 11%, the risk of endometrial cancer is 3%, and the risk of cervical cancer is 1%. AGC is found in <1% of cervical cytology specimens.
Atypical glandular cells (AGC) on cervical cytology usually originate from the glandular epithelium of the endocervix or endometrium. They are a less common finding than abnormal squamous cells.
Atypical glandular cells means that abnormal-looking cells were seen on your Pap smear. The abnormal cells may have come from the tissue lining the inside of the endometrium or the cervix. Conditions associated with this result include cancer, infection, inflammation, pregnancy, or previous radiation.
Finally,
AGC (atypical glandular cells) is another abnormal Pap smear result, but instead of squamous cells, it’s referring to a different type of cell that is naturally present in the cervix and also inside the uterus, ACOG explains. This type of change in these glandular cells can also signal precancer and potentially cancer.A finding of
atypical glandular cells (AGC) is when mucus-secreting cells from the inner part of the cervix or lining of the uterus exhibit changes that are significant but lack the distinctive features of cancer.Atypical glandular cells. Glandular cells produce mucus and grow in the opening of your cervix and within your uterus. Atypical glandular cells may appear to be slightly abnormal, but it's
unclear whether they're cancerous. Further testing is needed to determine the source of the abnormal cells and their significance.Atypical glandular cells (
AGC) on cervical cytology usually originate from the glandular epithelium of the endocervix or endometrium. They are a less common finding than abnormal squamous cells. Patients with AGC require further evaluation for premalignant conditions of the cervix, uterus, and, rarely, ovary and fallopian tube.