Among them is a gene called PTEN, which when turned off allowed cancer cells to become either round or elongated—perfect shapes to help them metastasize.
Round cells travel more easily through the bloodstream; elongated cells are better able to pierce bone marrow or invade organs..
Epithelial cells are round to polygonal and have a tendency to arrange in cohesive clusters.
Mesenchymal cells often have one or more cytoplasmic tails.
Those with one cytoplasmic tail may be described as flame shaped, those with two as spindle shaped, and those with more than two as stellate shaped..
Cutaneous round cell tumors range from potentially self-resolving benign lesions (canine cutaneous histiocytoma) to aggressive malignancies (cutaneous lymphoma)..
Desmoplastic small round cell tumors, or DSRCT, are tumors that grow in the abdomen and pelvic area of the body.
Desmoplastic small round cell tumors are a type of soft tissue sarcoma, which is a type of cancer that forms in the connective tissue of the body..
The term round cell tumor describes a group of highly aggressive malignant tumors composed of relatively small and monotonous undifferentiated cells with increased nuclear-cytoplasmic ratio.[1] Malignant small round cell tumors (MSRCT) is a term used for tumors composed of malignant round cells that are slightly larger .
Among them is a gene called PTEN, which when turned off allowed cancer cells to become either round or elongated—perfect shapes to help them metastasize.
Round cells travel more easily through the bloodstream; elongated cells are better able to pierce bone marrow or invade organs..
The immunophenotypic panel of markers which were used in the study to differentiate and categorise the small round blue cell tumours were-CD45/LCA (the lymphocyte common antigen), CD20, CD3, CK, CD99, desmin, EMA (epithelial membrane antigen), synaptophysin, chromogranin, GFAP (Glial fibrillary acidic protein)..
Large round cell – Squamous cell carcinoma, adenocarcinoma, melanoma, RMS, lymphoid tumors, paraganglioma..
Many of these tumors have quite uniform or bland cytologic features, but show aggressive malignant behavior (e.g. thyroid carcinomas in dogs), therefore cytologic criteria of malignancy are unreliable and we go by the known biologic behavior of the tumors.
However, the recent characterization of chromosomal breakpoints and the corresponding genes involved in malignant small round cell tumors means that it is possible to use molecular genetic approaches for detection.
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Other differential diagnoses of small round cell tumors include:
Round cell tumors as the name suggest are comprised round cells with increased nuclear-cytoplasmic ratio.
This group of tumor includes ,entities such as:
