Radiation cytology effect

Do tumors continue to shrink after radiation?
At the same time, if a cell doesn't divide, it also cannot grow and spread.
For tumors that divide slowly, the mass may shrink over a long, extended period after radiation stops.
The median time for a prostate cancer to shrink is about 18 months (some quicker, some slower)..
Does cytology work with radiation?
Therefore, radiation compromises the accuracy of cytology by both making the collection of representative material difficult leading to paucicellular smears and further difficulty in interpretation._{Apr 30, 2022}.
How does radiation affect Pap smears?
The acute effects of radiation tend to decline gradually and, in most cases, the morphological changes disappear from the cervicovaginal smears within 3-6 months after treatment.
However, bizarre and enlarged cells may continue to appear on cytological smears for a period of years after the treatment(10)..
What are the side effects of radiation for cervical cancer?
Since the radiation only travels a short distance with brachytherapy, the main effects of the radiation are on the cervix and the walls of the vagina.
The most common side effect is irritation of the vagina.
It may become red and sore, and there may be a discharge.
The vulva may become irritated as well..
What does radiation do to cervical cancer?
Also known as radiotherapy, radiation therapy uses a controlled dose of radiation to kill or damage cancer cells.
The radiation is usually in the form of x-ray beams.
It is targeted at the parts of the body with cancer or areas the cancer cells might have spread to..
An important cellular effect of radiation is neoplastic transformation, or the conversion of a normal cell to one with the phenotype of a cancer cell, including the ability to form an invasive, malignant tumor upon re-injection into syngeneic hosts.
How radiation therapy works against cancer.
At high doses, radiation therapy kills cancer cells or slows their growth by damaging their DNA.
Cancer cells whose DNA is damaged beyond repair stop dividing or die.
When the damaged cells die, they are broken down and removed by the body.
While radioresponsive tumors start to shrink in a few days, most head and neck cancers may take weeks or longer to shrink.
Some low-grade, slowly proliferating tumors histologically appear to be viable for prolonged periods after irradiation.

Radiation can cause cytoplasmic and nuclear changes. Cellular enlargement, vacuolation, granularity loss, and other changes linked with cell death are examples of cytoplasmic alterations. Nuclear enlargement and multinucleation are the most frequent nuclear alterations.

Can radiation cause cytoplasmic and nuclear alterations?

Radiation can cause cytoplasmic and nuclear changes.
Cellular enlargement, vacuolation, granularity loss, and other changes linked with cell death are examples of cytoplasmic alterations.
Nuclear enlargement and multinucleation are the most frequent nuclear alterations.

How does radiation therapy affect DNA?

Radiation therapy induces a wide spectrum of DNA changes, including:

nuclear base damage
single and double strand breaks and DNA crosslinks Affected cells undergo DNA repair
which may result in restoring cell function or transmitting these abnormalities to the descendent cells

Prostate Gland

Prostate with RC - low mag.

Rectum

Radiation proctitis- low mag. (WC)

What are the cellular effects of radiation?

An important cellular effect of radiation is neoplastic transformation, or the conversion of a normal cell to one with the phenotype of a cancer cell, including:

the ability to form an invasive
malignant tumor upon re-injection into syngeneic hosts

Most human cancers have been shown to be clonal in origin.

What are the cytologic features of radiation therapy?

The cytologic features described are most representative of cellular changes seen after radiation therapy, which may persist for many years.
Additionally, the background reflects a nonneoplastic process, further supporting the diagnosis.

Radiation cytology effect

Do tumors continue to shrink after radiation?

Does cytology work with radiation?

How does radiation affect Pap smears?

What are the side effects of radiation for cervical cancer?