[PDF] b cell activation markers

For most mature B cells the key markers include IgM and CD19, a protein receptor for antigens (Kaminski DA. Front Immunol. 2012). Activated B cells express CD30, a regulator of apoptosis.
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  • What are the 3 B cell CD markers?

    Immature B cells have the surface markers CD19, CD20, CD34, CD38, and CD45R. IgM is not present in their transcriptome. The main markers for most mature B cells include IgM and CD19, a protein receptor for antigens. B cells that have been activated express CD30, an apoptosis regulator.

  • What is CD27 a marker for?

    CD27+ B cells are larger cells with abundant cytoplasm carrying somatic hypermutation, and have an ability to produce immunoglobulin, indicating that CD27 is a memory marker of B cells. The ligation of CD27 yields crucial signals that positively control the entry of B cells into the pathway to plasma cells.

  • What is the surface marker for B cells?

    Most mouse and human B cell panels should include cell surface markers CD19 or CD20. B220 can be used as a marker for mouse B cells and not a pan B cell marker in humans.
  • In mice, CD19, CD80, CD73, and PD-L2/CD273 are commonly used to identify memory B cells. Differential expression of these markers suggests that there are at least five distinct mouse memory B cell subsets.
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