[PDF] b cell activation steps pdf

  • How are B cells activated step by step?

    B cells are activated when they encounter an antigen that they recognize. The antigen binds to the B cell's surface receptors, which activates and triggers it to divide and differentiate into an antibody-secreting plasma cell. Plasma cells produce antibodies that bind to the antigen and neutralize it.

  • What are ways to activate B cells?

    Activation of B cells
    A B cell becomes activated when its receptor recognizes an antigen and binds to it. In most cases, however, B-cell activation is dependent on a second factor mentioned above—stimulation by an activated helper T cell.

  • What are the two steps of B cell activation?

    B cell activation is dependent on the sequential integration of at least two signals. The first signal is generated by BCR cross-linking with antigen; the second is provided by interaction of B cells with T-helper cells (Parker, 1993).
  • The first step, known as the extrafollicular response, occurs outside lymphoid follicles but still in the SLO. During this step activated B cells proliferate, may undergo immunoglobulin class switching, and differentiate into plasmablasts that produce early, weak antibodies mostly of class IgM.
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