[PDF] b cell development checkpoints

Pre-BCR ligand binding and signal transduction (checkpoint 1). If signal transduction of the pre-BCR has been successful, the B cell initiates VJ recombination of the light chain that pairs with the heavy chain to form the BCR. The second checkpoint in B cell development is a test for potential autoreactivity.
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  • What are the B cell checkpoints?

    B cells express activating receptors and inhibitory receptors, which serve as immune checkpoints that regulate their activation and function. Activating receptors include the B cell receptor, Toll-like receptors, cytokine receptors, CD19, CD40 and other co-stimulatory receptors.

  • What are the two checkpoints of B cell development?

    V(D)J rearrangements at the Ig loci occur stepwise at different cellular stages of B cell development. The emerging repertoires of IgH and L chains are screened successively at two checkpoints, at the first for their fitness by pre-BCR formation, and at the second for autoantigen recognition after BCR formation.

  • What are the markers for B cell development?

    Immature B cells express CD19, CD 20, CD34, CD38, and CD45R, but not IgM. For most mature B cells the key markers include IgM and CD19, a protein receptor for antigens (Kaminski DA. Front Immunol. 2012).
  • First, they start as common lymphoid progenitor cells, which become early pro-B cells, then late pro-B cells, next large pre-B cells, then small pre-B cells, and finally, immature B cells. Immature B cells then migrate from the bone marrow into the lymph nodes and spleen to complete the process of maturation.
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