[PDF] b cell development nature reviews immunology

  • What is the B cell development in immunology?

    Introduction. B cell development starts in the bone marrow (BM) and continues in the spleen to final maturation. Developmental progression is guided by sequential events leading to assembly, expression, and signaling of the B cell antigen receptor (BCR).

  • What are the 6 phases of B cell development?

    B cell development takes place in a series of six main stages. First, they start as common lymphoid progenitor cells, which become early pro-B cells, then late pro-B cells, next large pre-B cells, then small pre-B cells, and finally, immature B cells.

  • What are the stages of B cell development and maturation?

    B Cell Development, Activation and Effector Functions
    The major developmental stages of the maturation phase include the HSC, the MPP, the CLP, the pro-B cell (progenitor B cell), the pre-B cell (precursor B cell), the immature naïve B cell, the transitional B cell and the mature naïve B cell.
  • As shown in Figure 1, mammalian B-cell development encompasses a continuum of stages that begin in primary lymphoid tissue (eg, human fetal liver and fetal/adult marrow), with subsequent functional maturation in secondary lymphoid tissue (eg, human lymph nodes and spleen).
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