[PDF] b cell activation pathway

B-cell activation is triggered by the binding of ligand (referred to as antigen) to the B-cell receptor (BCR), which initiates a cascade of intracellular signalling leading to the internalization of antigen for processing and presentation to T cells.
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  • What are the steps of B cell activation?

    B cells are activated when they encounter an antigen that they recognize. The antigen binds to the B cell's surface receptors, which activates and triggers it to divide and differentiate into an antibody-secreting plasma cell. Plasma cells produce antibodies that bind to the antigen and neutralize it.

  • Where do B cells get activated?

    B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. After B cells mature in the bone marrow, they migrate through the blood to SLOs, which receive a constant supply of antigen through circulating lymph.

  • What is the BCR pathway?

    Pathway Description:
    The B cell antigen receptor (BCR) is composed of membrane immunoglobulin (mIg) molecules and associated Ig?/Ig? (CD79a/CD79b) heterodimers (?/?). The mIg subunits bind antigen, resulting in receptor aggregation, while the ?/? subunits transduce signals to the cell interior.
  • Upon activation, a naïve B cell can become a plasma B cell or a memory B cell.
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