[PDF] b cell activation slideshare

  • What is B cell activation?

    B cell activation is initiated by the binding of antigen to the B cell receptor (BCR) that triggers a number of signaling cascades that ultimately lead to B cell activation.

  • What is the activation of B cells Slideshare?

    ACTIVATION OF B CELL ?Activation of B cell leads to proliferation and differentiation in to a plasma cell ,the end stage of B cell differentiation. ? It occurs in specialized regions of secondary lymphoid organs(spleen , Lymphoid nodes),the germinal centers.17 mar. 2015

  • What are the two steps of B cell activation?

    B cell activation is dependent on the sequential integration of at least two signals. The first signal is generated by BCR cross-linking with antigen; the second is provided by interaction of B cells with T-helper cells (Parker, 1993).
  • Activation of B cells via the BCR and/or PAMPs elicits proliferation of B cells. PAMPs, for instance lipopolysaccharide, also elicit differentiation of B cells into short-lived plasma cells secreting low-affinity antibodies.
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